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A Novel Cell Vertex Model Formulation that Distinguishes the Strength of Contraction Forces and Adhesion at Cell Boundaries

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Title: A Novel Cell Vertex Model Formulation that Distinguishes the Strength of Contraction Forces and Adhesion at Cell Boundaries
Authors: Sato, Katsuhiko Browse this author →KAKEN DB
Umetsu, Daiki Browse this author →KAKEN DB
Keywords: epithelial cells
mathematical model
resting length
contraction force
adhesion strength
turnover rate
cell intercalation
Issue Date: 22-Jul-2021
Publisher: Frontiers Media
Journal Title: Frontiers in physics
Volume: 9
Start Page: 704878
Publisher DOI: 10.3389/fphy.2021.704878
Abstract: The vertex model is a useful mathematical model to describe the dynamics of epithelial cell sheets. However, existing vertex models do not distinguish contraction forces on the cell boundary from adhesion between cells, employing a single parameter to express both. In this paper, we introduce the rest length of the cell boundary and its dynamics into the existing vertex model, giving a novel formulation of the model that treats separately the contraction force and the strength of adhesion between cells. We apply this vertex model to the phenomenon of compartment boundary in the fruit fly pupa, recapturing the observation that increasing the strength of adhesion between cells straightens the compartment boundary, even though contraction forces at cell boundaries remain unchanged. We also discuss possibilities of the novel vertex models by considering the stretching of a cell sheet by external forces.
Rights: Copyright © 2021 Sato and Umetsu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Type: article
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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