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Immune Thrombocytopenia Treated with Intravenous Erythromycin
Title: | Immune Thrombocytopenia Treated with Intravenous Erythromycin |
Authors: | Ohe, Masashi Browse this author | Furuya, Ken Browse this author | Goudarzi, Houman Browse this author →KAKEN DB |
Keywords: | Immune thrombocytopenia | clarithromycin | erythromycin | prednisolone | bioavailability |
Issue Date: | 9-Sep-2021 |
Publisher: | Gazi University |
Journal Title: | Gazi Medical Journal |
Volume: | 32 |
Issue: | 4 |
Start Page: | 577 |
End Page: | 579 |
Publisher DOI: | 10.12996/gmj.2021.129 |
Abstract: | Macrolides (MACs) such as clarithromycin (CAM) and erythromycin (EM) have immunomodulatory effects as well as anti-bacterial activity. In consideration of immunomodulatory effects, we report a patient with primary immune thrombocytopenia (ITP) treated with corticosteroids (CSs) combined with MACs. An 84-year-old woman with ITP was admitted to our hospital for further examination of reduced platelet counts. After admission, the patient was diagnosed with exacerbated primary ITP. The patient was successfully treated with intravenous immunoglobulin. However, the patient was unsuccessfully treated with CSs (i.e., prednisolone (PSL)and methyl PSL) combined with CAM. Eltrombopag (ELT), a thrombopoietin-receptor agonist, was successfully added. However, the patient suffered from aspiration pneumonia, making it impossible to administer oral drugs (i.e., PSL, CAM, and ELT). Alternatively, she was successfully treated with intravenous PSL combined with intravenous EM. This case shows that the efficacy of intravenous EM treatment may be higher than that of oral CAM treatment. |
Type: | article |
URI: | http://hdl.handle.net/2115/82681 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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