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Phlorotannins Derived From the Brown Alga Colpomenia bullosa as Tyrosinase Inhibitors

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Title: Phlorotannins Derived From the Brown Alga Colpomenia bullosa as Tyrosinase Inhibitors
Authors: Kurihara, Hideyuki Browse this author
Kujira, Kazuki Browse this author
Keywords: Colpomenia bullosa
Issue Date: May-2021
Publisher: SAGE Publications
Journal Title: Natural product communications
Volume: 16
Issue: 5
Publisher DOI: 10.1177/1934578X211021317
Abstract: Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase inhibitors extracted from brown alga Colfpomenia bullosa (Scytosiphonaceae, Scytosiphonales) were investigated. Inhibitory principles were isolated from the extract and identified as phlorotannins, phloroglucinol (1), diphlorethol (2), triphlorethol C (3), which have not been isolated in a free form previously, and fucophlorethol C (4). Compounds 3 and 4 have not been reported previously as tyrosinase inhibitors. Triphlorethol C (3) was the most potent tyrosinase inhibitor among the phlorotannins isolated, whereas isomeric fucophlorethol C (4) displayed the weakest inhibitory activity. The results suggest that molecular structures of phlorotannins strongly affect their tyrosinase inhibitory activity.
Type: article
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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