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Validation of Fully Automatic Quantitative Software for Finger Joint Space Narrowing Progression for Rheumatoid Arthritis Patients

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Title: Validation of Fully Automatic Quantitative Software for Finger Joint Space Narrowing Progression for Rheumatoid Arthritis Patients
Authors: Narisawa, Chiaki Browse this author
Sutherland, Kenneth Browse this author →KAKEN DB
Lu, Yutong Browse this author
Furusaki, Akira Browse this author
Sagawa, Akira Browse this author
Kamishima, Tamotsu Browse this author →KAKEN DB
Keywords: Rheumatoid arthritis
Joint space narrowing
Computer-based analysis
Issue Date: 28-Sep-2020
Publisher: Springer
Journal Title: Journal of digital imaging
Volume: 33
Issue: 6
Start Page: 1387
End Page: 1392
Publisher DOI: 10.1007/s10278-020-00390-6
Abstract: In rheumatoid arthritis (RA), the radiographic progression of joint space narrowing (JSN) is evaluated using visual assessments. However, those methods are complicated and time-consuming. We developed an automatic system that can detect joint locations and compute the joint space difference index (JSDI), which was defined as the chronological change in JSN between two radiographs. The purpose of this study was to establish the validity of the software that automatically evaluates the temporal change of JSN. This study consisted of 39 patients with RA. All patients were treated with tocilizumab and underwent hand radiography (left and right hand separately) at 0, 6, and 12 months. The JSN was evaluated using mTSS (modified Total Sharp Score) by one musculoskeletal radiologist as well as our automatic system. Software measurement showed that JSDI between 0 and 12 months was significantly higher than that between 0 and 6 months (p< 0.01). While, there was no significant difference in mTSS between 0, 6, and 12 months. The group with higher disease activity at 0 months had significantly higher JSDI between 0 and 6 months than that with lower disease activity (p= 0.02). The automatic software can evaluate JSN progression of RA patients in the finger joint on X-ray.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Journal of Digital Imaging. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神島 保

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