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Temporal Prediction Signals for Periodic Sensory Events in the Primate Central Thalamus

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Title: Temporal Prediction Signals for Periodic Sensory Events in the Primate Central Thalamus
Authors: Matsuyama, Kei Browse this author
Tanaka, Masaki Browse this author →KAKEN DB
Keywords: temporal prediction
phase transition
motor thalamus
single neuron
Issue Date: 3-Mar-2021
Publisher: Society for Neuroscience
Journal Title: Journal of neuroscience
Volume: 41
Issue: 9
Start Page: 1917
End Page: 1927
Publisher DOI: 10.1523/JNEUROSCI.2151-20.2021
Abstract: Prediction of periodic event timing is an important function for everyday activities, while the exact neural mechanism remains unclear. Previous studies in nonhuman primates have demonstrated that neurons in the cerebellar dentate nucleus and those in the caudate nucleus exhibit periodic firing modulation when the animals attempt to detect a single omission of isochronous repetitive audiovisual stimuli. To understand how these subcortical signals are sent and processed through the thalamocortical pathways, we examined single-neuron activities in the central thalamus of two macaque monkeys (one female and one male). We found that three types of neurons responded to each stimulus in the sequence in the absence of movements. Reactive-type neurons showed sensory adaptation and gradually waned the transient response to each stimulus. Predictive-type neurons steadily increased the magnitude of the suppressive response, similar to neurons previously reported in the cerebellum. Switch-type neurons initially showed a transient response, but after several cycles, the direction of firing modulation reversed and the activity decreased for each repetitive stimulus. The time course of Switch-type activity was well explained by the weighted sum of activities of the other types of neurons. Furthermore, for only Switch-type neurons the activity just before stimulus omission significantly correlated with behavioral latency, indicating that this type of neuron may carry a more advanced signal in the system detecting stimulus omission. These results suggest that the central thalamus may transmit integrated signals to the cerebral cortex for temporal information processing, which are necessary to accurately predict rhythmic event timing.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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