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Glucokinase is required for high-starch diet-induced beta-cell mass expansion in mice

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Title: Glucokinase is required for high-starch diet-induced beta-cell mass expansion in mice
Authors: Tsuchida, Kazuhisa Browse this author
Nakamura, Akinobu Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author
Yang, Kelaier Browse this author
Yamauchi, Yuki Browse this author
Kawata, Shinichiro Browse this author
Omori, Kazuno Browse this author
Takahashi, Kiyohiko Browse this author
Kitao, Naoyuki Browse this author
Nomoto, Hiroshi Browse this author
Kameda, Hiraku Browse this author
Cho, Kyu Yong Browse this author
Seino, Yusuke Browse this author
Terauchi, Yasuo Browse this author
Atsumi, Tatsuya Browse this author
Keywords: β-Cell mass
High-starch diet
Issue Date: Sep-2021
Publisher: John Wiley & Sons
Journal Title: Journal of diabetes investigation
Volume: 12
Issue: 9
Start Page: 1545
End Page: 1554
Publisher DOI: 10.1111/jdi.13532
Abstract: Aims/Introduction We aimed to determine whether glucokinase is required for beta-cell mass expansion induced by high-starch diet (HSTD)-feeding, as has been shown in its high-fat diet-induced expansion. Materials and Methods Eight-week-old male wild-type (Gck(+/+)) or glucokinase haploinsufficient (Gck(+/-)) mice were fed either a normal chow (NC) or an HSTD for 15 weeks. The bodyweight, glucose tolerance, insulin sensitivity, insulin secretion and beta-cell mass were assessed. Results Both HSTD-fed Gck(+/+) and Gck(+/-) mice had significantly higher bodyweight than NC-fed mice. Insulin and oral glucose tolerance tests revealed that HSTD feeding did not affect insulin sensitivity nor glucose tolerance in either the Gck(+/+) or Gck(+/-) mice. However, during the oral glucose tolerance test, the 15-min plasma insulin concentration after glucose loading was significantly higher in the HSTD group than that in the NC group for Gck(+/+), but not for Gck(+/-) mice. beta-Cell mass was significantly larger in HSTD-fed Gck(+/+) mice than that in NC-fed Gck(+/+) mice. In contrast, the beta-cell mass of the HSTD-fed Gck(+/-) mice was not different from that of the NC-fed Gck(+/-) mice. Conclusions The results showed that HSTD feeding would increase pancreatic beta-cell mass and insulin secretion in Gck(+/+), but not Gck(+/-) mice. This observation implies that glucokinase in beta-cells would be required for the increase in beta-cell mass induced by HSTD feeding.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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