| Title: | Systemic mucoid degeneration of the arterial tunica intima in a young dog |
| Authors: | Ichikawa, Yoshiki Browse this author |
| Heishima, Mizuki Browse this author |
| Vyhnal, Kristin Browse this author |
| Aoshima, Keisuke Browse this author |
| Sasaoka, Kazuyoshi Browse this author →KAKEN DB |
| Kinoshita, Ryohei Browse this author →KAKEN DB |
| Kobayashi, Atsushi Browse this author |
| Takiguchi, Mitsuyoshi Browse this author →KAKEN DB |
| Kimura, Takashi Browse this author →KAKEN DB |
| Keywords: | arterial occlusion |
| artery |
| dogs |
| mucoid degeneration |
| thromboembolism |
| tunica intima |
| Issue Date: | 4-Sep-2021 |
| Publisher: | SAGE Publications |
| Journal Title: | Journal of Veterinary Diagnostic Investigation |
| Volume: | 34 |
| Issue: | 1 |
| Start Page: | 94 |
| End Page: | 97 |
| Publisher DOI: | 10.1177/10406387211042587 |
| Abstract: | A 27-mo-old, spayed female mixed-breed dog was presented with left forelimb pain, which progressed to full thickness necrosis of the soft tissues of multiple limbs. Clinical imaging and postmortem examination suggested multiple large arterial thromboemboli. Histologic examination of vascular lesions revealed markedly thickened tunica intima with polypoid intraluminal projections, which partially to entirely occluded the arterial lumen. The expanded tunica intima was comprised of intimal accumulation of Alcian blue-positive matrix with scattered spindle-to-satellite cells. These cells were positive for von Willebrand factor and vimentin but negative for alpha-smooth muscle actin, suggesting endothelial origin. Deposition of the intimal mucoid matrix was observed in the elastic and muscular arteries associated with regional ischemic changes. Mucoid emboli, likely from fragmentation of proliferative intimal tissue, were identified in smaller vessels supplied by affected arteries. Based on these findings, we diagnosed systemic mucoid degeneration of the arterial tunica intima. Such systemic arterial degeneration characterized by deposition of mucoid matrix in the tunica intima has not been reported previously in dogs, to our knowledge, and should be distinguished from thromboembolism and other degenerative vascular diseases. |
| Rights: | Ichikawa Y, Heishima M, Vyhnal K, et al. Systemic mucoid degeneration of the arterial tunica intima in a young dog. Journal of Veterinary Diagnostic Investigation. September 2021. doi:10.1177/10406387211042587 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/82893 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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