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Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone

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Title: Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone
Authors: Oe, Sao Browse this author
Masum, Md. Abdul Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Nishimura, Takanori Browse this author
Nakamura, Teppei Browse this author
Namba, Takashi Browse this author
Otani, Yuki Browse this author
Nakayama, Yasuhide Browse this author
Elewa, Yaser Hosny Ali Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: fibrosis
foreign body reaction
neutrophil extracellular traps
Issue Date: 5-Oct-2020
Publisher: John Wiley & Sons
Journal Title: Journal of biomedical materials research part A
Volume: 109
Issue: 7
Start Page: 1220
End Page: 1231
Publisher DOI: 10.1002/jbm.a.37115
Abstract: We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) was observed at 2, 7, 14, 21, 28, 43, and 70 days (D) postsurgery. The thin layer (TL) and loose connective tissues (LCTs) (inside and outside the TSS) developed until D21 and densified afterward. Neutrophils infiltrated the TSS until D14 and formed neutrophil extracellular traps (NETs) in the TL during D7-21. In the LCTs, mast cell counts increased until D21, and macrophage numbers peaked at D14. Several macrophages showed LYVE-1 expression, supporting a tissue-remodeling role. Developmental indices of collagen fibers (CFs) and reticular fibers (RFs) increased during D2-21. NETs, but not neutrophils, were detected after D28. Mast cell numbers peaked at D43 and were maintained until D70. Myofibroblasts consistently localized to the TL from D14. During D21-28, the area of connective tissue (CNT), and CFs and RFs decreased and increased, respectively, and both remained constant during D28-70. The CF density remained constant from D21 and increased at D70. Thus, TSS showed two phases: inflammation and CNT development (D2-21), and inflammation convergence and CNT stabilization (D28-70). These results provide insights into foreign body reactions in clinical cases.
Rights: This is the peer reviewed version of the following article:, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 市居 修

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