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Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation

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Title: Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
Authors: Sedlačík, Tomáš Browse this author
Nonoyama, Takayuki Browse this author →KAKEN DB
Guo, Honglei Browse this author
Kiyama, Ryuji Browse this author
Nakajima, Tasuku Browse this author →KAKEN DB
Takeda, Yoshihiro Browse this author
Kurokawa, Takayuki Browse this author →KAKEN DB
Gong, Jian Ping Browse this author →KAKEN DB
Issue Date: 13-Oct-2020
Publisher: American Chemical Society(ACS)
Journal Title: Chemistry of Materials
Volume: 32
Issue: 19
Start Page: 8576
End Page: 8586
Publisher DOI: 10.1021/acs.chemmater.0c02911
Abstract: Supermacroporous hydrogels, possessing sponge-like structure and permeability, have drawn significant atten-tion for their bioengineering and biomedical applications. However, their mechanical weakness due to their low-density structure is one of their biggest limitations. This work reports a multi-step cryogelation technique, which does not require special equipment, for preparing tough supermacroporous hydrogels on the basis of the double-network (DN) strategy. The produced supermacroporous DN gels possess interconnected pores with pore sizes of 50–230 μm. They also show a com-pressive modulus of up to ~100 kPa, which is 2- to 4-times higher than that of the corresponding supermacroporous single-network (SN) gels, and compressive strength of up to 1 MPa at 80% compression. The supermacroporous DN cryogels are also stretchable with a work of extension of up to 38 kJ m-3, which is 1 to 2 orders larger than that of the SN cryogels. The high stiffness and stretchability distinguish them from other types of cryogels. Supermacroporous triple-network (TN) gels and DN gels composed of different polymer combinations are also prepared. The technique presented herein is suitable for pre-paring supermacroporous DN gels from various polymers; hence, it is promising in meeting bioengineering and biomedical demands.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 龔 剣萍 (Gong Jian Ping)

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