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Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
| Title: | Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation |
| Authors: | Sedlačík, Tomáš Browse this author | | Nonoyama, Takayuki Browse this author →KAKEN DB | | Guo, Honglei Browse this author | | Kiyama, Ryuji Browse this author | | Nakajima, Tasuku Browse this author →KAKEN DB | | Takeda, Yoshihiro Browse this author | | Kurokawa, Takayuki Browse this author →KAKEN DB | | Gong, Jian Ping Browse this author →KAKEN DB |
| Issue Date: | 13-Oct-2020 |
| Publisher: | American Chemical Society(ACS) |
| Journal Title: | Chemistry of Materials |
| Volume: | 32 |
| Issue: | 19 |
| Start Page: | 8576 |
| End Page: | 8586 |
| Publisher DOI: | 10.1021/acs.chemmater.0c02911 |
| Abstract: | Supermacroporous hydrogels, possessing sponge-like structure and permeability, have drawn significant atten-tion for their bioengineering and biomedical applications. However, their mechanical weakness due to their low-density structure is one of their biggest limitations. This work reports a multi-step cryogelation technique, which does not require special equipment, for preparing tough supermacroporous hydrogels on the basis of the double-network (DN) strategy. The produced supermacroporous DN gels possess interconnected pores with pore sizes of 50–230 μm. They also show a com-pressive modulus of up to ~100 kPa, which is 2- to 4-times higher than that of the corresponding supermacroporous single-network (SN) gels, and compressive strength of up to 1 MPa at 80% compression. The supermacroporous DN cryogels are also stretchable with a work of extension of up to 38 kJ m-3, which is 1 to 2 orders larger than that of the SN cryogels. The high stiffness and stretchability distinguish them from other types of cryogels. Supermacroporous triple-network (TN) gels and DN gels composed of different polymer combinations are also prepared. The technique presented herein is suitable for pre-paring supermacroporous DN gels from various polymers; hence, it is promising in meeting bioengineering and biomedical demands. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/.10.1021/acs.chemmater.0c02911. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/82930 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 龔 剣萍 (Gong Jian Ping)
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