| Title: | Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals |
| Authors: | Tokuchi, Yoshimasa Browse this author |
| Suda, Goki Browse this author →KAKEN DB |
| Kimura, Megumi Browse this author |
| Maehara, Osamu Browse this author |
| Kitagataya, Takashi Browse this author |
| Kubo, Akinori Browse this author |
| Yoshida, Sonoe Browse this author |
| Fu, Qingjie Browse this author |
| Yang, Zijian Browse this author |
| Hosoda, Shunichi Browse this author |
| Ohara, Masatsugu Browse this author |
| Yamada, Ren Browse this author |
| Suzuki, Kazuharu Browse this author |
| Kawagishi, Naoki Browse this author |
| Nakai, Masato Browse this author |
| Sho, Takuya Browse this author |
| Natsuizaka, Mitsuteru Browse this author |
| Morikawa, Kenichi Browse this author |
| Ogawa, Koji Browse this author |
| Ohnishi, Shunsuke Browse this author |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Issue Date: | 16-Aug-2021 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 11 |
| Issue: | 1 |
| Start Page: | 16616 |
| Publisher DOI: | 10.1038/s41598-021-96203-z |
| Abstract: | We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients after treatment with DAA were recruited into the study. Patients who achieved sustained virological response (SVR); and had complete clinical information, preserved serum samples at baseline and SVR48, and skeletal muscle mass evaluations based on the psoas muscle mass index (PMI) on computed tomography at baseline and >= 12 months were included. Altogether, 70.7% of patients (41/58) showed increased PMI after DAA therapy, and mean relative PMI was significantly higher after DAA therapy than at baseline. There were no significant associations between baseline clinical factors routinely examined in clinical practice and increased PMI. Among factors reported to be associated with skeletal muscle loss in patients with chronic liver disease, serum zinc levels and total and free carnitine levels increased significantly after DAA therapy and only changes in serum free carnitine levels were significantly associated with an increased PMI (r = 0305, P = 0.020). In conclusion, increased skeletal muscle mass after successful HCV eradication by DAAs was significantly associated with increased serum-free carnitine levels. l-carnitine supplementation may be beneficial in patients with low skeletal muscle mass after DAA. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/82972 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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