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Determination of brain tumor recurrence using C-11-methionine positron emission tomography after radiotherapy

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Title: Determination of brain tumor recurrence using C-11-methionine positron emission tomography after radiotherapy
Authors: Yamaguchi, Shigeru Browse this author
Hirata, Kenji Browse this author
Okamoto, Michinari Browse this author
Shimosegawa, Eku Browse this author
Hatazawa, Jun Browse this author
Hirayama, Ryuichi Browse this author
Kagawa, Naoki Browse this author
Kishima, Haruhiko Browse this author
Oriuchi, Noboru Browse this author
Fujii, Masazumi Browse this author
Kobayashi, Kentaro Browse this author
Kobayashi, Hiroyuki Browse this author
Terasaka, Shunsuke Browse this author
Nishijima, Ken-ichi Browse this author
Kuge, Yuji Browse this author
Ito, Yoichi M. Browse this author
Nishihara, Hiroshi Browse this author
Tamaki, Nagara Browse this author
Shiga, Tohru Browse this author
Keywords: brain tumors
positron emission tomography
radiation injuries
Issue Date: 1-Oct-2021
Publisher: John Wiley & Sons
Journal Title: Cancer science
Volume: 112
Issue: 10
Start Page: 4246
End Page: 4256
Publisher DOI: 10.1111/cas.15001
Abstract: We conducted a prospective multicenter trial to compare the usefulness of C-11-methionine (MET) and F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) for identifying tumor recurrence. Patients with clinically suspected tumor recurrence after radiotherapy underwent both C-11-MET and F-18-FDG PET. When a lesion showed a visually detected uptake of either tracer, it was surgically resected for histopathological analysis. Patients with a lesion negative to both tracers were revaluated by magnetic resonance imaging (MRI) at 3 months after the PET studies. The primary outcome measure was the sensitivity of each tracer in cases with histopathologically confirmed recurrence, as determined by the McNemar test. Sixty-one cases were enrolled, and 56 cases could be evaluated. The 38 cases where the lesions showed uptake of either C-11-MET or F-18-FDG underwent surgery; 32 of these cases were confirmed to be subject to recurrence. Eighteen cases where the lesions showed uptake of neither tracer received follow-up MRI; the lesion size increased in one of these cases. Among the cases with histologically confirmed recurrence, the sensitivities of C-11-MET PET and F-18-FDG PET were 0.97 (32/33, 95% confidence interval [CI]: 0.85-0.99) and 0.48 (16/33, 95% CI: 0.33-0.65), respectively, and the difference was statistically significant (P < .0001). The diagnostic accuracy of C-11-MET PET was significantly better than that of F-18-FDG PET (87.5% vs. 69.6%, P = .033). No examination-related adverse events were observed. The results of the study demonstrated that C-11-MET PET was superior to F-18-FDG PET for discriminating between tumor recurrence and radiation-induced necrosis.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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