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Proinsulin C-peptide activates vagus efferent output in rats
Title: | Proinsulin C-peptide activates vagus efferent output in rats |
Authors: | Kimura, K. Browse this author →KAKEN DB | Niijima, A. Browse this author | Yoshida, R. Browse this author | Kitamura, T. Browse this author | Kamikawa, A. Browse this author | Furuya, D. T. Browse this author | Kitamura, N. Browse this author | Konno, A. Browse this author | Nakamoto, H. Browse this author | Sakane, N. Browse this author | Yoshida, T. Browse this author | Saito, M. Browse this author |
Keywords: | atropine | C-peptide | gastric acid | norepinephrine | parasympathetic nerve | sympathetic nerve | vagus |
Issue Date: | Dec-2005 |
Publisher: | Elsevier |
Journal Title: | Peptides |
Volume: | 26 |
Issue: | 12 |
Start Page: | 2547 |
End Page: | 2553 |
Publisher DOI: | 10.1016/j.peptides.2005.05.023 |
PMID: | 16005542 |
Abstract: | The aim of this study was to examine the effect of proinsulin C-peptide on the autonomic nervous systems in rats. Intravenous administration of C-peptide gradually increased electrophysiological activity of the vagus nerves into the stomach and pancreas for at least 90 min. It also slightly increased gastric acid secretion that was suppressed by the treatment with atropine. Intraperitoneal injection of C-peptide did not affect the basal and stress-induced norepinephrine turnover rate, a biochemical index of sympathetic nerve activity. These results indicate that C-peptide increases parasympathetic nerve activity without affecting sympathetic nerve activity. This could explain, at least in part, the ameliorating effects of C-peptide on impaired cardiac autonomic nerve functions in patients with type 1 diabetes. |
Description URI: | http://www.sciencedirect.com/science/journal/01969781 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/8298 |
Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 木村 和弘
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