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Proinsulin C-peptide activates vagus efferent output in rats

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Title: Proinsulin C-peptide activates vagus efferent output in rats
Authors: Kimura, K. Browse this author →KAKEN DB
Niijima, A. Browse this author
Yoshida, R. Browse this author
Kitamura, T. Browse this author
Kamikawa, A. Browse this author
Furuya, D. T. Browse this author
Kitamura, N. Browse this author
Konno, A. Browse this author
Nakamoto, H. Browse this author
Sakane, N. Browse this author
Yoshida, T. Browse this author
Saito, M. Browse this author
Keywords: atropine
gastric acid
parasympathetic nerve
sympathetic nerve
Issue Date: Dec-2005
Publisher: Elsevier
Journal Title: Peptides
Volume: 26
Issue: 12
Start Page: 2547
End Page: 2553
Publisher DOI: 10.1016/j.peptides.2005.05.023
PMID: 16005542
Abstract: The aim of this study was to examine the effect of proinsulin C-peptide on the autonomic nervous systems in rats. Intravenous administration of C-peptide gradually increased electrophysiological activity of the vagus nerves into the stomach and pancreas for at least 90 min. It also slightly increased gastric acid secretion that was suppressed by the treatment with atropine. Intraperitoneal injection of C-peptide did not affect the basal and stress-induced norepinephrine turnover rate, a biochemical index of sympathetic nerve activity. These results indicate that C-peptide increases parasympathetic nerve activity without affecting sympathetic nerve activity. This could explain, at least in part, the ameliorating effects of C-peptide on impaired cardiac autonomic nerve functions in patients with type 1 diabetes.
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Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 和弘

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