HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Characteristics of discharge prescriptions for patients with schizophrenia or major depressive disorder: Real-world evidence from the Effectiveness of Guidelines for Dissemination and Education (EGUIDE) psychiatric treatment project

Files in This Item:

The file(s) associated with this item can be obtained from the following URL: https://doi.org/10.1016/j.ajp.2021.102744


Title: Characteristics of discharge prescriptions for patients with schizophrenia or major depressive disorder: Real-world evidence from the Effectiveness of Guidelines for Dissemination and Education (EGUIDE) psychiatric treatment project
Authors: Hashimoto, Naoki Browse this author
Yasui-Furukori, Norio Browse this author
Hasegawa, Naomi Browse this author
Ishikawa, Shuhei Browse this author
Numata, Shusuke Browse this author
Hori, Hikaru Browse this author
Iida, Hitoshi Browse this author
Ichihashi, Kayo Browse this author
Furihata, Ryuji Browse this author
Murata, Atsunobu Browse this author
Tsuboi, Takashi Browse this author
Takeshima, Masahiro Browse this author
Kyou, Yoshitaka Browse this author
Komatsu, Hiroshi Browse this author
Kubota, Chika Browse this author
Ochi, Shinichiro Browse this author
Takaesu, Yoshikazu Browse this author
Usami, Masahide Browse this author
Nagasawa, Tatsuya Browse this author
Hishimoto, Akitoyo Browse this author
Miura, Kenichiro Browse this author
Matsumoto, Junya Browse this author
Ohi, Kazutaka Browse this author
Yamada, Hisashi Browse this author
Inada, Ken Browse this author
Watanabe, Koichiro Browse this author
Shimoda, Kazutaka Browse this author
Hashimoto, Ryota Browse this author
Keywords: Antipsychotics
Antidepressants
Monopharmacy
Polypharmacy
EGUIDE
Issue Date: Sep-2021
Publisher: Elsevier
Journal Title: Asian Journal of Psychiatry
Volume: 63
Start Page: 102744
Publisher DOI: 10.1016/j.ajp.2021.102744
Abstract: Background: Monopharmacy with antipsychotics and antidepressants is the first-line treatment for schizophrenia and major depressive disorder (MDD) in most clinical guidelines, while polypharmacy with psychotropic agents in the treatment of schizophrenia is common in clinical practice. There are no detailed data on the prescription patterns for inpatients with mental illness with reliable diagnoses made by treating psychiatrists. Methods: We gathered prescription data at discharge from 2177 patients with schizophrenia and 1238 patients with MDD from October 2016 to March 2018. Results: The patients with schizophrenia aged between 60 and 79 were prescribed lower doses of antipsychotics and hypnotics/anxiolytics than those aged between 40 and 59. There were significant differences between the prescription rate of antipsychotics in the patients with schizophrenia and that of antidepressants in the patients with MDD. The frequency of concomitant drugs such as anti-Parkinson drugs, anxiolytics/hypnotics and mood stabilizers in the subjects with schizophrenia prescribed antipsychotic polypharmacy was significantly higher than that with monotherapy. For the patients with schizophrenia, olanzapine, risperidone, aripiprazole, quetiapine, and blonanserin were the five most prescribed antipsychotics. For the patients with MDD, mirtazapine, duloxetine, escitalopram, trazodone and sertraline were the five most prescribed antidepressants. Conclusions: Our results showed the use of high doses of antipsychotics, high percentages of antipsychotic polypharmacy and concurrent use of hypnotics/anxiolytics in patients with schizophrenia. Notably, these data were collected before intensive instruction regarding the guidelines; therefore, we need to assess the change in the prescription pattern post guideline instruction.
Type: article
URI: http://hdl.handle.net/2115/82981
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University