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Genistein Directly Represses the Phosphorylation of STAT5 in Lactating Mammary Epithelial Cells

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Title: Genistein Directly Represses the Phosphorylation of STAT5 in Lactating Mammary Epithelial Cells
Authors: Tsugami, Yusaku Browse this author
Wakasa, Haruka Browse this author
Nishimura, Takanori Browse this author →KAKEN DB
Kobayashi, Ken Browse this author →KAKEN DB
Issue Date: 7-Sep-2021
Publisher: American Chemical Society
Journal Title: ACS Omega
Volume: 6
Issue: 35
Start Page: 22765
End Page: 22772
Publisher DOI: 10.1021/acsomega.1c03107
Abstract: Genistein is a soy isoflavone and shows various physiological activities, such as affinities for estrogen receptors (ERs) and inhibitory effects on the epidermal growth factor receptor (EGFR) pathway. A previous study reported that genistein downregulates milk production ability in mammary epithelial cells (MECs) while decreasing the phosphorylation of STAT5. The ER and EGFR pathways indirectly regulate STAT5. In this study, the repressing mechanism of genistein against the phosphorylation of STAT5 was investigated using a culture model of mouse MECs with milk production ability. The results revealed that genistein did not influence the behavior of ERa and ER beta, whereas genistein immediately repressed the phosphorylation of ERK1/2. However, the decrease in phosphorylated STAT5 occurred independent of the phosphorylation of EGFR. Genistein repressed new phosphorylation of STAT5 by prolactin without influencing the phosphorylation of JAK2. In conclusion, this study indicates that genistein directly inhibits the phosphorylation of STAT5 in lactating MECs.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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