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Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress

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Title: Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress
Authors: Aikawa, Katsuhiro Browse this author
Yoshida, Takayuki Browse this author →KAKEN DB
Ohmura, Yu Browse this author →KAKEN DB
Lyttle, Kerise Browse this author
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Morimoto, Yuji Browse this author →KAKEN DB
Keywords: Antidepressant effect
E/I ratio
Glutamatergic neurotransmission
Medial prefrontal cortex
Issue Date: 1-Nov-2020
Publisher: Elsevier
Journal Title: Brain research
Volume: 1746
Start Page: 146980
Publisher DOI: 10.1016/j.brainres.2020.146980
Abstract: Juvenile stress, like that caused by childhood maltreatment, is a significant risk factor for psychiatric disorders such as depression later in life. Recently, the antidepressant effect of ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, has been widely investigated. However, little is known regarding its efficacy against depressive-like alterations caused by juvenile stress, which is clinically relevant in human depression. In the present study, we evaluated the antidepressant-like effect of ketamine in adult rats that had been subjected to juvenile stress. Depressive-like behavior was assessed using the forced swim test (FST), and electrophysiological and morphological alterations in the layer V pyramidal cells of the prelimbic cortex were examined using whole-cell patch-clamp recordings and subsequent recording-cell specific fluorescence imaging. We demonstrated that ketamine (10 mg/kg) attenuated the increased immobility time caused by juvenile stress in the FST, restored the diminished excitatory postsynaptic currents, and caused atrophic changes in the apical dendritic spines. Ketamine's effects reversing impaired excitatory/inhibitory ratio of postsynaptic currents were also revealed. These results indicated that ketamine could be effective in reversing the depression-like alterations caused by juvenile stress.
Rights: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 相川 勝洋

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