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Hokkaido University Collection of Scholarly and Academic Papers >
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Performance of Qualitative and Quantitative Antigen Tests for SARS-CoV-2 Using Saliva
| Title: | Performance of Qualitative and Quantitative Antigen Tests for SARS-CoV-2 Using Saliva |
| Authors: | Yokota, Isao Browse this author →KAKEN DB | | Sakurazawa, Takayo Browse this author | | Sugita, Junichi Browse this author →KAKEN DB | | Iwasaki, Sumio Browse this author | | Yasuda, Keiko Browse this author | | Yamashita, Naoki Browse this author | | Fujisawa, Shinichi Browse this author | | Nishida, Mutsumi Browse this author →KAKEN DB | | Konno, Satoshi Browse this author →KAKEN DB | | Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | SARS-CoV-2 | | COVID-19 | | saliva | | Lumipulse | | Espline | | ICA | | CLEIA |
| Issue Date: | Sep-2021 |
| Publisher: | MDPI |
| Journal Title: | Infectious Disease Reports |
| Volume: | 13 |
| Issue: | 3 |
| Start Page: | 742 |
| End Page: | 747 |
| Publisher DOI: | 10.3390/idr13030069 |
| Abstract: | The rapid detection of SARS-CoV-2 is critical for the prevention of disease outbreaks. Antigen tests such as immunochromatographic assay (ICA) and chemiluminescent enzyme immunoassay (CLEIA) can yield results more quickly than PCR. We evaluated the performance of ICA and CLEIA using 34 frozen PCR-positive (17 saliva samples and 17 nasopharyngeal swabs [NPS]) and 309 PCR-negative samples. ICA detected SARS-CoV-2 in only 14 (41%) samples, with positivity rates of 24% in saliva and 59% in NPS. Notably, ICA detected SARS-CoV-2 in 5 of 6 samples collected within 4 days after symptom onset. CLEIA detected SARS-CoV-2 in 31 (91%) samples, with a positivity of 82% in saliva and 100% in NPS. These results suggest that the use of ICA should be limited to an earlier time after symptom onset and CLEIA is more sensitive and can be used in situations where quick results are required. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83161 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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