HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Elevated serum CYFRA 21-1 level as a diagnostic marker for thymic carcinoma

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Elevated serum CYFRA 21-1 level as a diagnostic marker for thymic carcinoma
Authors: Shiiya, Haruhiko Browse this author →KAKEN DB
Ujiie, Hideki Browse this author
Hida, Yasuhiro Browse this author →KAKEN DB
Kato, Tatsuya Browse this author
Kaga, Kichizo Browse this author →KAKEN DB
Wakasa, Satoru Browse this author →KAKEN DB
Kikuchi, Eiki Browse this author →KAKEN DB
Shinagawa, Naofumi Browse this author →KAKEN DB
Okada, Kazufumi Browse this author
Ito, Yoichi M. Browse this author →KAKEN DB
Matsuno, Yoshihiro Browse this author →KAKEN DB
Keywords: CYFRA 21-1
mediastinal tumor
thymic carcinoma
tumor marker
Issue Date: 4-Nov-2021
Publisher: John Wiley & Sons
Journal Title: Thoracic cancer
Publisher DOI: 10.1111/1759-7714.14158
Abstract: Background No useful tumor markers have been identified for the diagnosis of thymic carcinomas. Serum cytokeratin 19 fragment, measured using the CYFRA 21-1 immunoassay, is used as a tumor marker for squamous cell carcinomas in various malignant tumors. Here, we evaluated the value of CYFRA 21-1 in diagnosing thymic carcinoma. Methods We retrospectively reviewed 94 patients with pathological diagnoses of thymic carcinoma or thymoma (32 and 62 patients, respectively) who were referred to our departments between January 2000 and March 2019. Primary outcomes included tumor marker levels and their diagnostic accuracy. Results Patients with thymic carcinoma were significantly more likely to be male (thymic carcinoma, 68.8%; thymoma, 40.3%; p = 0.02), have an advanced TNM stage (p < 0.01), and a significantly higher CYFRA 21-1 level than those with thymoma (thymic carcinoma: median = 4.2 ng/ml; interquartile range [IQR] = 2.1-6.1 ng/ml vs. thymoma: median = 1.2 ng/ml; IQR = 0.9-1.7 ng/ml; p < 0.01). Receiver operating characteristic curves demonstrated that the area under the curve for CYFRA 21-1 to distinguish thymic carcinoma from thymoma was 0.86 (95% confidence interval [CI]: 0.74-0.93; cutoff = 2.7 ng/ml; sensitivity = 68.8%; specificity = 95.2%). Multivariable analysis demonstrated that CYFRA 21-1 (odds ratio = 25.6; 95% CI: 4.6-141.6; p < 0.01) was an independent predictor for thymic carcinoma after adjusting for TNM stage. Conclusions Serum CYFRA 21-1 level may help in diagnosing thymic carcinoma.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University