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Hokkaido University Collection of Scholarly and Academic Papers >
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Polyzwitterions as a Versatile Building Block of Tough Hydrogels: From Polyelectrolyte Complex Gels to Double-Network Gels
| Title: | Polyzwitterions as a Versatile Building Block of Tough Hydrogels: From Polyelectrolyte Complex Gels to Double-Network Gels |
| Authors: | Yin, Haiyan Browse this author | | King, Daniel R Browse this author →KAKEN DB | | Sun, Tao Lin Browse this author | | Saruwatari, Yoshiyuki Browse this author | | Nakajima, Tasuku Browse this author →KAKEN DB | | Kurokawa, Takayuki Browse this author →KAKEN DB | | Gong, Jian Ping Browse this author →KAKEN DB |
| Keywords: | double-network hydrogel | | interpenetrating network hydrogel | | polyelectrolyte complex | | polyzwitterion | | toughness | | biomaterials |
| Issue Date: | 4-Nov-2020 |
| Publisher: | American Chemical Society(ACS) |
| Journal Title: | ACS Applied Materials & Interfaces |
| Volume: | 12 |
| Issue: | 44 |
| Start Page: | 50068 |
| End Page: | 50076 |
| Publisher DOI: | 10.1021/acsami.0c15269 |
| Abstract: | The high water content of hydrogels makes them important as synthetic biomaterials, and tuning the mechanical properties of hydrogels to match those of natural tissues without changing chemistry is usually difficult. In this study, we have developed a series of hydrogels with varied stiffness, strength, and toughness based on a combination of poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS), a strong acidic polyelectrolyte, and poly-N-(carboxymethyl)-N,N-dimethyl-2-(methacryloyloxy) ethanaminium) (PCDME), a polyzwitterion with a weak acidic moiety. We demonstrate that modifying the true molar ratio, R, of PCDME to PAMPS results in four unique categories of hydrogels with different swelling ratios and Young’s moduli. When R < 1, a negatively charged polyelectrolyte gel (PE) is formed; when 1 < R < 3, a tough and viscoelastic polyelectrolyte complex gel (PEC) is formed; when 3 < R < 6.5, a conventional, elastic interpenetrating network gel (IPN) is formed; and when R > 6.5, a tough and stiff double-network gel (DN) is formed. Both the PEC and DN gels exhibit high toughness and fracture stress, up to 1.8 and 1.5 MPa, respectively. Importantly, the PEC gels exhibit strong recovery properties along with high toughness, distinguishing them from DN gels. Without requiring a change in chemistry, we can tune the mechanical response of hydrogels over a wide spectrum, making this a useful system of soft and hydrated iomaterials. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS applied materials & interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see To access the final edited and published work see https://dx.doi.org/10.1021/acsami.0c15269. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/83164 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 龔 剣萍 (Gong Jian Ping)
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