| Title: | A novel nairovirus associated with acute febrile illness in Hokkaido, Japan |
| Authors: | Kodama, Fumihiro Browse this author |
| Yamaguchi, Hiroki Browse this author →KAKEN DB |
| Park, Eunsil Browse this author →KAKEN DB |
| Tatemoto, Kango Browse this author |
| Sashika, Mariko Browse this author →KAKEN DB |
| Nakao, Ryo Browse this author →KAKEN DB |
| Terauchi, Yurino Browse this author |
| Mizuma, Keita Browse this author |
| Orba, Yasuko Browse this author →KAKEN DB |
| Kariwa, Hiroaki Browse this author →KAKEN DB |
| Hagiwara, Katsuro Browse this author →KAKEN DB |
| Okazaki, Katsunori Browse this author →KAKEN DB |
| Goto, Akiko Browse this author →KAKEN DB |
| Komagome, Rika Browse this author →KAKEN DB |
| Miyoshi, Masahiro Browse this author →KAKEN DB |
| Ito, Takuya Browse this author |
| Yamano, Kimiaki Browse this author →KAKEN DB |
| Yoshii, Kentaro Browse this author →KAKEN DB |
| Funaki, Chiaki Browse this author |
| Ishizuka, Mariko Browse this author |
| Shigeno, Asako Browse this author |
| Itakura, Yukari Browse this author |
| Bell-Sakyi, Lesley Browse this author |
| Edagawa, Shunji Browse this author |
| Nagasaka, Atsushi Browse this author |
| Sakoda, Yoshihiro Browse this author →KAKEN DB |
| Sawa, Hirofumi Browse this author →KAKEN DB |
| Maeda, Ken Browse this author →KAKEN DB |
| Saijo, Masayuki Browse this author →KAKEN DB |
| Matsuno, Keita Browse this author →KAKEN DB |
| Issue Date: | 20-Sep-2021 |
| Publisher: | Nature Portfolio |
| Journal Title: | Nature communications |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 5539 |
| Publisher DOI: | 10.1038/s41467-021-25857-0 |
| Abstract: | The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83176 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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