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Association of high serum soluble interleukin 2 receptor levels with risk of adverse events in cardiac sarcoidosis

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Title: Association of high serum soluble interleukin 2 receptor levels with risk of adverse events in cardiac sarcoidosis
Authors: Kobayashi, Yuta Browse this author
Sato, Takuma Browse this author
Nagai, Toshiyuki Browse this author →KAKEN DB
Hirata, Kenji Browse this author →KAKEN DB
Tsuneta, Satonori Browse this author
Kato, Yoshiya Browse this author
Komoriyama, Hirokazu Browse this author
Kamiya, Kiwamu Browse this author →KAKEN DB
Konishi, Takao Browse this author
Omote, Kazunori Browse this author →KAKEN DB
Ohira, Hiroshi Browse this author →KAKEN DB
Kudo, Kohsuke Browse this author →KAKEN DB
Konno, Satoshi Browse this author →KAKEN DB
Anzai, Toshihisa Browse this author →KAKEN DB
Keywords: Cardiac sarcoidosis
Soluble interleukin 2 receptor
Prognosis
Positron emission tomography
Issue Date: 4-Nov-2021
Publisher: Wiley Periodicals, Inc
Journal Title: ESC heart failure
Publisher DOI: 10.1002/ehf2.13614
Abstract: Aims Although soluble interleukin 2 receptor (sIL-2R) is a potentially useful biomarker in the diagnosis and evaluation of disease severity in patients with sarcoidosis, its prognostic implication in patients with cardiac sarcoidosis (CS) is unclear. We sought to investigate whether sIL-2R was associated with clinical outcomes and to clarify the relationship between sIL-2R levels and disease activity in patients with CS. Methods and results We examined 83 consecutive patients with CS in our hospital who had available serum sIL-2R data between May 2003 and February 2020. The primary outcome was a composite of advanced atrioventricular block, ventricular tachycardia or ventricular fibrillation, heart failure hospitalization, and all-cause death. Inflammatory activity in the myocardium and lymph nodes was assessed by F-18-fluorideoxyglucose positron emission tomography/computed tomography. During a median follow-up period of 2.96 (IQR 2.24-4.27) years, the primary outcome occurred in 24 patients (29%). Higher serum sIL-2R levels (>538 U/mL, the median) were significantly related to increased incidence of primary outcome (P = 0.037). Multivariable Cox regression analysis showed that a higher sIL-2R was independently associated with an increased subsequent risk of adverse events (HR 3.71, 95% CI 1.63-8.44, P = 0.002), even after adjustment for significant covariates. sIL-2R levels were significantly correlated to inflammatory activity in lymph nodes (r = 0.346, P = 0.003) but not the myocardium (r = 0.131, P = 0.27). Conclusions Increased sIL-2R is associated with worse long-term clinical outcomes accompanied by increased systemic inflammatory activity in CS patients.
Type: article
URI: http://hdl.handle.net/2115/83186
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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