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Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine

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Title: Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine
Authors: Endo, Tsutomu Browse this author →KAKEN DB
Koike, Yoshinao Browse this author
Miyoshi, Hideaki Browse this author →KAKEN DB
Hisada, Yuichiro Browse this author
Fujita, Ryo Browse this author
Suzuki, Ryota Browse this author
Tanaka, Masaru Browse this author
Tsujimoto, Takeru Browse this author
Shimamura, Yukitoshi Browse this author
Hasegawa, Yuichi Browse this author
Kanayama, Masahiro Browse this author
Hashimoto, Tomoyuki Browse this author
Oha, Fumihiro Browse this author
Noro, Naoki Browse this author
Komano, Kiyofumi Browse this author
Ishii, Misaki Browse this author
Ito, Yoichi M. Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Takahata, Masahiko Browse this author →KAKEN DB
Issue Date: 31-Aug-2021
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 11
Issue: 1
Start Page: 17412
Publisher DOI: 10.1038/s41598-021-96714-9
Abstract: Ossification of the posterior longitudinal ligament (OPLL) of the spine is a disease of unknown etiology occurring frequently in individuals with metabolic disturbances. Obesity has been suggested as a potential risk factor for the severity of OPLL. We aimed to investigate whether non-alcoholic fatty liver disease (NAFLD) is associated with OPLL severity. We assessed the severity of NAFLD by a liver-to-spleen (L/S) ratio on computed tomography (CT) scans of 85 symptomatic OPLL patients at a single institution in Japan. We also assessed the severity of OPLL by CT reconstruction sagittal and axial images. The prevalence of NAFLD in middle-aged patients (age < 70 years, n = 50) was 80.3%, which was 2.5-8 times higher than that in the general Japanese population (9-30%). The ossification index of the spinal ligaments increased in proportion to the severity of fatty liver. The L/S ratio was revealed as a significant risk factor associated with the total ossification index (standardized beta: -0.40, 95% confidence interval - 54.34 to - 4.22). This study suggests the potential contribution of NAFLD to the progression of OPLL. The close association between NAFLD and OPLL demonstrated in this study warrants further study to elucidate the causal nature of this relationship.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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