| Title: | Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine |
| Authors: | Endo, Tsutomu Browse this author →KAKEN DB |
| Koike, Yoshinao Browse this author |
| Miyoshi, Hideaki Browse this author →KAKEN DB |
| Hisada, Yuichiro Browse this author |
| Fujita, Ryo Browse this author |
| Suzuki, Ryota Browse this author |
| Tanaka, Masaru Browse this author |
| Tsujimoto, Takeru Browse this author |
| Shimamura, Yukitoshi Browse this author |
| Hasegawa, Yuichi Browse this author |
| Kanayama, Masahiro Browse this author |
| Hashimoto, Tomoyuki Browse this author |
| Oha, Fumihiro Browse this author |
| Noro, Naoki Browse this author |
| Komano, Kiyofumi Browse this author |
| Ishii, Misaki Browse this author |
| Ito, Yoichi M. Browse this author |
| Iwasaki, Norimasa Browse this author →KAKEN DB |
| Takahata, Masahiko Browse this author →KAKEN DB |
| Issue Date: | 31-Aug-2021 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 11 |
| Issue: | 1 |
| Start Page: | 17412 |
| Publisher DOI: | 10.1038/s41598-021-96714-9 |
| Abstract: | Ossification of the posterior longitudinal ligament (OPLL) of the spine is a disease of unknown etiology occurring frequently in individuals with metabolic disturbances. Obesity has been suggested as a potential risk factor for the severity of OPLL. We aimed to investigate whether non-alcoholic fatty liver disease (NAFLD) is associated with OPLL severity. We assessed the severity of NAFLD by a liver-to-spleen (L/S) ratio on computed tomography (CT) scans of 85 symptomatic OPLL patients at a single institution in Japan. We also assessed the severity of OPLL by CT reconstruction sagittal and axial images. The prevalence of NAFLD in middle-aged patients (age < 70 years, n = 50) was 80.3%, which was 2.5-8 times higher than that in the general Japanese population (9-30%). The ossification index of the spinal ligaments increased in proportion to the severity of fatty liver. The L/S ratio was revealed as a significant risk factor associated with the total ossification index (standardized beta: -0.40, 95% confidence interval - 54.34 to - 4.22). This study suggests the potential contribution of NAFLD to the progression of OPLL. The close association between NAFLD and OPLL demonstrated in this study warrants further study to elucidate the causal nature of this relationship. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83190 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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