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Aggravation of Ossified Ligamentum Flavum Lesion Is Associated With the Degree of Obesity

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Title: Aggravation of Ossified Ligamentum Flavum Lesion Is Associated With the Degree of Obesity
Authors: Endo, Tsutomu Browse this author →KAKEN DB
Koike, Yoshinao Browse this author
Hisada, Yuichiro Browse this author
Fujita, Ryo Browse this author
Suzuki, Ryota Browse this author
Tanaka, Masaru Browse this author
Tsujimoto, Takeru Browse this author
Shimamura, Yukitoshi Browse this author
Hasegawa, Yuichi Browse this author
Kanayama, Masahiro Browse this author
Yamada, Katsuhisa Browse this author
Iwata, Akira Browse this author →KAKEN DB
Sudo, Hideki Browse this author →KAKEN DB
Ishii, Misaki Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Takahata, Masahiko Browse this author →KAKEN DB
Keywords: severe obesity
body mass index
spinal ligament
posterior longitudinal ligament
ligamentum flavum
Issue Date: 9-Nov-2021
Publisher: SAGE Publications
Journal Title: Global Spine Journal
Volume: 13
Issue: 5
Start Page: 1325
End Page: 1331
Publisher DOI: 10.1177/21925682211031514
Abstract: Study Design: Retrospective cross-sectional study. Objectives: There is insufficient data on the clinical features of ossification of the ligamentum flavum (OLF) of the thoracic spine and the risk of progression of ossified lesions. The link between obesity and ossification of the posterior longitudinal ligament (OPLL), which frequently coexists with OLF, has been demonstrated. However, the link between obesity and OLF has not been recognized. We aimed to determine the prevalence of obesity in thoracic OLF and whether the severity of OLF is associated with the degree of obesity. Methods: A total of 204 symptomatic Japanese subjects with thoracic OLF and 136 subjects without spinal ligament ossification as controls were included. OLF subjects were divided into 3 groups: 1) localized OLF (OLF <2-intervertebral regions); 2) multilevel OLF (OLF >= 3-intervertebral regions); and 3) OLF + OPLL. The severity of OLF was quantified using the OLF index using computed tomography imaging of the entire spine. Results: The proportion of severely obese subjects (BMI >= 30 kg/m(2)) was significantly higher both in the multilevel OLF group (25.5%) and the OLF + OPLL group (44.3%) than in the localized OLF group (3.6%) and the control group (1.4%) (P < 0.01). BMI, age, and coexistence of cervical OPLL and lumbar OLF were associated with thoracic OLF index in the multiple regression analysis. Conclusions: Our findings demonstrated that obesity is a distinct feature of multilevel OLF in the thoracic spine and that the severity of OLF is associated with the degree of obesity.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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