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The TLR4-TRIF-type 1 IFN-IFN-gamma pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection
| Title: | The TLR4-TRIF-type 1 IFN-IFN-gamma pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection |
| Authors: | Yamamoto, Koji Browse this author →KAKEN DB | | Kondo, Yasuyuki Browse this author | | Ohnishi, Shunsuke Browse this author →KAKEN DB | | Yoshida, Masaru Browse this author | | Sugiyama, Toshiro Browse this author | | Sakamoto, Naoya Browse this author →KAKEN DB |
| Issue Date: | 24-Sep-2021 |
| Publisher: | Cell Press |
| Journal Title: | iScience |
| Volume: | 24 |
| Issue: | 9 |
| Start Page: | 103064 |
| Publisher DOI: | 10.1016/j.isci.2021.103064 |
| Abstract: | Helicobacter suis, a zoonotic infection-related bacterium, can induce gastric mucosa-associated lymphoid tissue (MALT) lymphoma in humans and animals. Recently, we reported that the formation of gastric MALT lymphoma after H. suis infection is induced by interferon (IFN)-gamma activation. Here, we revealed that activation of the Toll-like receptor (TLR) 4-Toll/IL-1 receptor domain-containing adapter-inducing interferon-beta (TRIF) pathway after H. suis infection is associated with the production of type 1 IFNs (IFN-alpha, IFN-beta) by gastric epithelial cells. Additionally, these type 1 IFNs interact with type 1 IFN receptors on gastric B cells, facilitating the secretion of IFN-gamma and the activation of which is enhanced by positive feedback regulation in B cells. These results suggest that the TLR4-TRIF-type 1 IFN-IFN-gamma pathway is crucial in the development of gastric MALT lymphoma after H. suis infection and may, therefore, represent a therapeutic target for the prevention of this condition. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83247 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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