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Are simple verbal instructions sufficient to ensure that bladder volume does not deteriorate prostate position reproducibility during spot scanning proton therapy?

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Title: Are simple verbal instructions sufficient to ensure that bladder volume does not deteriorate prostate position reproducibility during spot scanning proton therapy?
Authors: Nishioka, Kentaro Browse this author →KAKEN DB
Gotoh, Kento Browse this author
Hashimoto, Takayuki Browse this author
Abe, Takashige Browse this author
Osawa, Takahiro Browse this author
Matsumoto, Ryuji Browse this author
Yokota, Isao Browse this author
Katoh, Norio Browse this author
Kinoshita, Rumiko Browse this author
Yasuda, Koichi Browse this author
Yakabe, Toshiaki Browse this author
Yoshimura, Takaaki Browse this author
Takao, Seishin Browse this author
Shinohara, Nobuo Browse this author
Aoyama, Hidefumi Browse this author
Shimizu, Shinichi Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Issue Date: 11-Nov-2021
Publisher: British Institute of Radiology
Journal Title: BJR|Open
Volume: 3
Issue: 1
Start Page: 20210064
Publisher DOI: 10.1259/bjro.20210064
Abstract: Objectives:The purpose of this study is to investigate whether verbal instructions are sufficient for bladder volume (BV) control not to deteriorate prostate position reproducibility in image-guided spot scanning proton therapy (SSPT) for localized prostate cancer.Methods:A total of 268 treatment sessions in 12 consecutive prostate cancer patients who were treated with image-guided SSPT with fiducial markers were retrospectively analyzed. In addition to strict rectal volume control procedures, simple verbal instructions to void urine one hour before the treatment were used here. The BV was measured by a Bladder Scan just before the treatment, and the prostate motion was measured by intraprostatic fiducial markers and two sets of X-ray fluoroscopy images. The correlation between the BV change and prostate motion was assessed by linear mixed-effects models and systematic and random errors according to the reproducibility of the BV.Results:The mean absolute BV change during treatment was from ?98.7 to 86.3 ml (median 7.1 ml). The mean absolute prostate motion of the patients in the left-right direction was ?1.46 to 1.85 mm; in the cranial-caudal direction it was ?6.10 to 3.65 mm, and in the anteroposterior direction ?1.90 to 5.23 mm. There was no significant relationship between the BV change and prostate motion during SSPT. The early and late genitourinary and gastrointestinal toxicity was minimal with a minimum follow up of 4.57 years.Conclusions:Simple verbal instructions about urination was suggested to be sufficient to control the BV not to impact on the prostate motion and clinical outcomes in image-guided SSPT. Careful attention to BV change is still needed when the seminal vesicle is to be treated.Advances in knowledge:Our data demonstrated that there was no apparent relationship between BV changes and prostate position reproducibility and simple verbal instruction about urination could be sufficient for image-guided SSPT
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西岡 健太郎

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