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Fibrinolytic system activation immediately following trauma was quickly and intensely suppressed in a rat model of severe blunt trauma
| Title: | Fibrinolytic system activation immediately following trauma was quickly and intensely suppressed in a rat model of severe blunt trauma |
| Authors: | Hayakawa, Mineji Browse this author →KAKEN DB | | Tsuchida, Takumi Browse this author | | Honma, Yoshinori Browse this author | | Mizugaki, Asumi Browse this author | | Ooyasu, Takayoshi Browse this author | | Yoshida, Tomonao Browse this author | | Saito, Tomoyo Browse this author | | Katabami, Kenichi Browse this author | | Wada, Takeshi Browse this author | | Maekawa, Kunihiko Browse this author |
| Issue Date: | 13-Oct-2021 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 11 |
| Issue: | 1 |
| Start Page: | 20283 |
| Publisher DOI: | 10.1038/s41598-021-99426-2 |
| Abstract: | In severe trauma, excessive fibrinolytic activation is associated with an increase in the transfusion volume and mortality rate. However, in the first several hours after a blunt trauma, changes in fibrinolytic activation, suppression, and activation-suppression balance have not yet been elucidated, which the present study aimed to clarify. Anesthetized 9-week-old male Wistar S/T rats experienced severe blunt trauma while being placed inside the Noble-Collip drum. Rats were randomly divided into four groups of seven. The no-trauma group was not exposed to any trauma; the remaining groups were analysed 0, 60, and 180 min after trauma. Immediately following trauma, total tissue-plasminogen activator (tPA) levels significantly increased in the plasma, and the balance of active tPA and active plasminogen activator inhibitor-1 (PAI-1) significantly tipped toward fibrinolytic activation. After trauma, both tPA and PAI-1 levels increased gradually in various organs and active and total PAI-1 levels increased exponentially in the plasma. Total plasma tPA levels 60 min after trauma returned quickly to levels comparable to those in the no-trauma group. In conclusion, fibrinolytic activation was observed only immediately following trauma. Therefore, immediately after trauma, the fibrinolytic system was activated; however, its activation was quickly and intensely suppressed. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83355 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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