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Fibrinolytic system activation immediately following trauma was quickly and intensely suppressed in a rat model of severe blunt trauma

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Title: Fibrinolytic system activation immediately following trauma was quickly and intensely suppressed in a rat model of severe blunt trauma
Authors: Hayakawa, Mineji Browse this author →KAKEN DB
Tsuchida, Takumi Browse this author
Honma, Yoshinori Browse this author
Mizugaki, Asumi Browse this author
Ooyasu, Takayoshi Browse this author
Yoshida, Tomonao Browse this author
Saito, Tomoyo Browse this author
Katabami, Kenichi Browse this author
Wada, Takeshi Browse this author
Maekawa, Kunihiko Browse this author
Issue Date: 13-Oct-2021
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 11
Issue: 1
Start Page: 20283
Publisher DOI: 10.1038/s41598-021-99426-2
Abstract: In severe trauma, excessive fibrinolytic activation is associated with an increase in the transfusion volume and mortality rate. However, in the first several hours after a blunt trauma, changes in fibrinolytic activation, suppression, and activation-suppression balance have not yet been elucidated, which the present study aimed to clarify. Anesthetized 9-week-old male Wistar S/T rats experienced severe blunt trauma while being placed inside the Noble-Collip drum. Rats were randomly divided into four groups of seven. The no-trauma group was not exposed to any trauma; the remaining groups were analysed 0, 60, and 180 min after trauma. Immediately following trauma, total tissue-plasminogen activator (tPA) levels significantly increased in the plasma, and the balance of active tPA and active plasminogen activator inhibitor-1 (PAI-1) significantly tipped toward fibrinolytic activation. After trauma, both tPA and PAI-1 levels increased gradually in various organs and active and total PAI-1 levels increased exponentially in the plasma. Total plasma tPA levels 60 min after trauma returned quickly to levels comparable to those in the no-trauma group. In conclusion, fibrinolytic activation was observed only immediately following trauma. Therefore, immediately after trauma, the fibrinolytic system was activated; however, its activation was quickly and intensely suppressed.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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