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Identification of ACE inhibitory peptides from red alga Mazzaella japonica

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Title: Identification of ACE inhibitory peptides from red alga Mazzaella japonica
Authors: Kumagai, Yuya Browse this author →KAKEN DB
Kitade, Yumi Browse this author
Kobayashi, Manami Browse this author
Watanabe, Kei Browse this author
Kurita, Hiroki Browse this author
Takeda, Hirohumi Browse this author
Yasui, Hajime Browse this author →KAKEN DB
Kishimura, Hideki Browse this author →KAKEN DB
Keywords: ACE inhibitory activity
Red alga
Mazzaella japonica
Protein hydrolysate
Issue Date: 30-Nov-2021
Publisher: Springer
Journal Title: European Food Research and Technology
Volume: 246
Start Page: 2225
End Page: 2231
Publisher DOI: 10.1007/s00217-020-03567-z
Abstract: Angiotensin I converting enzyme (ACE) inhibition is one of the key factors for cardiovascular disease, and inhibition of ACE activity is related to the prevention of high blood pressure. Until now, some ACE inhibitory peptides have been found in the protein hydrolysates of red algae, and most of them were derived from phycobiliproteins and rubisco. In this study, we modified the preparation method to evaluate the potential of ACE inhibitory activity from protein hydrolysate of red algaMazzaella japonicaexcept for phycobiliproteins and rubisco. As a result, we identified 11 peptides (YRD, VSEGLD, TIMPHPR, GGPAT, SSNDYPI, SRIYNVKSNG, VDAHY, CPYDWV, YGDPDHY, NLGN and DFGVPGHEP) in the hydrolysate by the reversed phase-HPLC and MALDI-TOF/MS/MS. Among them, YRD would be derived from phycoerythrin alpha-subunit. However, the others would be from other proteins encoded in chloroplast or nuclear genomes. This study revealed that not only phycobiliproteins and rubisco but also the other proteins in red algae have the potential for the source of ACE inhibitory peptide.
Rights: This is a post-peer-review, pre-copyedit version of an article published in European Food Research and Technology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸村 栄毅

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