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Gelsolin: a candidate for suppressor of human bladder cancer
| Title: | Gelsolin: a candidate for suppressor of human bladder cancer |
| Authors: | Tanaka, Motoyoshi Browse this author | | Mullauer, Leonhard Browse this author | | Ogiso, Yoshifumi Browse this author | | Fujita, Hisakazu Browse this author | | Moriya, Shingo Browse this author | | Furuuchi, Keiji Browse this author | | Harabayashi, Tohru Browse this author | | Shinohara, Nobuo Browse this author | | Koyanagi, Tomohiko Browse this author | | Kuzumaki, Noboru10 Browse this author |
| Authors(alt): | 葛巻, 暹10 |
| Issue Date: | 1-Aug-1995 |
| Publisher: | American Association for Cancer Research |
| Journal Title: | Cancer Research |
| Volume: | 55 |
| Issue: | 15 |
| Start Page: | 3228 |
| End Page: | 3232 |
| Abstract: | Human transitional cell carcinomas of the bladder frequently reveal chromosomal abnormalities that span a range between chromosome 9pl2 and 9qter, even at early stages of bladder carcinogenesis. Because the gene that encodes an actin-regulatory protein, gelsolin, is localized in chromosome 9q33, we examined the expression of gelsolin in a number of human bladder cancer cell lines and tissues. In all 6 cell lines and in 14 of the 18 tumor tissues (77.8%), gelsolin expression was undetectable or extremely low in comparison with its expression in normal bladder epithelial cells. Furthemore, upon the introduction of the exogenous human or mouse authentic gelsolin cDNA into a human bladder cancer cell line, UMUC-2, gelsolin transfectants of UMUC-2 greatly reduced the colony-forming ability and the tumorigenicity in vivo. These results suggest that gelsolin plays a key role as a tumor suppressor in human urinary bladder carcinogenesis. |
| Rights: | Copyright (c) 1995 by American Association for Cancer Research |
| Type: | article (author version) |
| URI: | http://cancerres.aacrjournals.org/ | | http://hdl.handle.net/2115/834 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 葛巻 暹
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