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Gelsolin: a candidate for suppressor of human bladder cancer

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/834

Title: Gelsolin: a candidate for suppressor of human bladder cancer
Authors: Tanaka, Motoyoshi Browse this author
Mullauer, Leonhard Browse this author
Ogiso, Yoshifumi Browse this author
Fujita, Hisakazu Browse this author
Moriya, Shingo Browse this author
Furuuchi, Keiji Browse this author
Harabayashi, Tohru Browse this author
Shinohara, Nobuo Browse this author
Koyanagi, Tomohiko Browse this author
Kuzumaki, Noboru10 Browse this author
Authors(alt): 葛巻, 暹10
Issue Date: 1-Aug-1995
Publisher: American Association for Cancer Research
Journal Title: Cancer Research
Volume: 55
Issue: 15
Start Page: 3228
End Page: 3232
Abstract: Human transitional cell carcinomas of the bladder frequently reveal chromosomal abnormalities that span a range between chromosome 9pl2 and 9qter, even at early stages of bladder carcinogenesis. Because the gene that encodes an actin-regulatory protein, gelsolin, is localized in chromosome 9q33, we examined the expression of gelsolin in a number of human bladder cancer cell lines and tissues. In all 6 cell lines and in 14 of the 18 tumor tissues (77.8%), gelsolin expression was undetectable or extremely low in comparison with its expression in normal bladder epithelial cells. Furthemore, upon the introduction of the exogenous human or mouse authentic gelsolin cDNA into a human bladder cancer cell line, UMUC-2, gelsolin transfectants of UMUC-2 greatly reduced the colony-forming ability and the tumorigenicity in vivo. These results suggest that gelsolin plays a key role as a tumor suppressor in human urinary bladder carcinogenesis.
Rights: Copyright (c) 1995 by American Association for Cancer Research
Type: article (author version)
URI: http://cancerres.aacrjournals.org/
http://hdl.handle.net/2115/834
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 葛巻 暹

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