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Pilot study using virtual 4-D tracking electromagnetic navigation bronchoscopy in the diagnosis of pulmonary nodules : a single center prospective study
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Title: | Pilot study using virtual 4-D tracking electromagnetic navigation bronchoscopy in the diagnosis of pulmonary nodules : a single center prospective study |
Authors: | Ishiwata, Tsukasa Browse this author | Ujiie, Hideki Browse this author | Gregor, Alexander Browse this author | Inage, Terunaga Browse this author | Motooka, Yamato Browse this author | Kinoshita, Tomonari Browse this author | Aragaki, Masato Browse this author | Chen, Zhenchian Browse this author | Effat, Andrew Browse this author | Bernards, Nicholas Browse this author | Yasufuku, Kazuhiro Browse this author |
Keywords: | Electromagnetic navigation bronchoscopy | prospective study | 4D tracking | diagnostic performance |
Issue Date: | May-2021 |
Publisher: | AME Publishing Company |
Journal Title: | Journal of Thoracic Disease |
Volume: | 13 |
Issue: | 5 |
Start Page: | 2885 |
End Page: | 2895 |
Publisher DOI: | 10.21037/jtd-21-141 |
Abstract: | Background: Electromagnetic navigation bronchoscopy (ENB) is a navigation technology intended to improve the diagnostic yield of pulmonary nodules. However, nodule displacement due to respiratory motion may compromise the accuracy of the navigation guidance. The Veran SPiNDrive ENB system employs respiratory-gating (4D-tracking) to compensate for this motion. The aim of the present study was to evaluate the diagnostic performance and safety of the Veran SPiNDrive system for biopsy of pulmonary nodules.
Methods: Adult patients with pulmonary nodules of ≥1 cm were enrolled at a single center. Both conventional bronchoscopy and 4D-tracking ENB were performed in one procedure session under general anesthesia, with the procedure order being randomly assigned. Radial probe endobronchial ultrasound and fluoroscopy were used in both groups. The diagnostic performance, safety, total procedure time, and total fluoroscopy time of the ENB phase were compared to the corresponding conventional bronchoscopy phase.
Results: The study was terminated due to poor accrual; a total of eleven patients were enrolled. The mean size of pulmonary nodules was 2.1 cm. The sensitivity for malignancy was 67% (6/9) and 56% (5/9) with conventional bronchoscopy and with 4D-tracking ENB, respectively. Two cases developed minor bleeding after conventional bronchoscopy, while no complications were observed after 4D-tracking ENB. The mean procedure time was 16.1 and 21.7 min (P=0.090), and the mean duration time for fluoroscopy use was 77 and 44 sec (P=0.056) for the conventional bronchoscopy and the 4D-tracking ENB phases, respectively.
Conclusions: The diagnostic performance of the Veran SPiNDrive 4D-tracking ENB did not exceed that of conventional bronchoscopy for pulmonary nodules. No complications were seen during 4D-tracking ENB. A study with a larger number of participants is required for further assessment. |
Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/83403 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 氏家 秀樹
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