|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
REV-ERB agonist suppresses IL-17 production in gamma delta T cells and improves psoriatic dermatitis in a mouse model
| Title: | REV-ERB agonist suppresses IL-17 production in gamma delta T cells and improves psoriatic dermatitis in a mouse model |
| Authors: | Wang, Shangyi Browse this author | | Kozai, Mina Browse this author | | Mita, Hironobu Browse this author | | Cai, Zimeng Browse this author | | Masum, Md Abdul Browse this author | | Ichii, Osamu Browse this author →KAKEN DB | | Takada, Kensuke Browse this author →KAKEN DB | | Inaba, Mutsumi Browse this author →KAKEN DB |
| Keywords: | IL-17 | | gamma delta T cells | | Psoriasis | | Nuclear receptor | | REV-ERB |
| Issue Date: | 7-Oct-2021 |
| Publisher: | Elsevier |
| Journal Title: | Biomedicine & pharmacotherapy |
| Volume: | 144 |
| Start Page: | 112283 |
| Publisher DOI: | 10.1016/j.biopha.2021.112283 |
| Abstract: | Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperplasia and cellular infiltration. Studies have shown that disease development depends on proinflammatory cytokines, such as interleukin (IL)-23 and IL-17. It has been suggested that IL-23 produced by innate immune cells, such as macrophages, stimulates a subset of helper T cells to release IL-17, promoting neutrophil recruitment and keratinocyte proliferation. However, recent studies have revealed the crucial role of gamma delta T cells in psoriasis pathogenesis as the primary source of dermal IL-17. The nuclear receptors REV-ERBs are ligand-dependent transcription factors recognized as circadian rhythm regulators. REV-ERBs negatively regulate IL-17-producing helper T cells, whereas the involvement of REV-ERBs in regulating IL-17-producing gamma delta T (gamma delta T17) cells remains unclear. Here we revealed the regulatory mechanism involving gamma delta T17 cells through REV-ERBs. gamma delta T17 cell levels were remarkably elevated in the secondary lymphoid organs of mice that lacked an isoform of REV-ERBs. A synthetic REV-ERB agonist, 5R9009, suppressed gamma delta T17 cells in vitro and in vivo. Topical application of SR9009 to the skin reduced the inflammatory symptoms of psoriasiform dermatitis in mice. The results of this study provide a novel therapeutic approach for psoriasis targeting REV-ERBs in gamma delta T17 cells. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83490 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
