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Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease
Title: | Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease |
Authors: | Osuga, Tatsuyuki Browse this author | Morita, Tomoya Browse this author | Sasaki, Noboru Browse this author →KAKEN DB | Morishita, Keitaro Browse this author →KAKEN DB | Ohta, Hiroshi Browse this author →KAKEN DB | Takiguchi, Mitsuyoshi Browse this author →KAKEN DB |
Keywords: | canine | Ea | Ees | elastance | mitral regurgitation | survival time |
Issue Date: | 6-Nov-2021 |
Publisher: | John Wiley & Sons |
Journal Title: | Journal of Veterinary Internal Medicine |
Volume: | 35 |
Issue: | 6 |
Start Page: | 2607 |
End Page: | 2615 |
Publisher DOI: | 10.1111/jvim.16290 |
Abstract: | Background The interaction between the left ventricle (LV) and systemic arterial systems, known as left ventricular-arterial coupling (VAC), has been evaluated based on the effective arterial elastance (Ea) to LV end-systolic elastance (Ees) ratio (Ea/Ees). The Ea reflects the total arterial load of LV, whereas Ees reflects the LV systolic function. A recent study found that inappropriate VAC based on increased Ea/Ees estimated by echocardiography is associated with advanced disease severity in dogs with myxomatous mitral valve disease (MMVD). Hypothesis Inappropriate VAC assessed by echocardiographic estimation of Ea/Ees is associated with a worse prognosis in dogs with MMVD. Animals Eighty-nine dogs with MMVD. Methods Prospective cohort study. Dogs underwent echocardiographic examinations at enrollment. The Ea was estimated using the formula: mean blood pressure/(forward stroke volume/body weight). The Ees was estimated using the formula: mean blood pressure/(LV end-systolic volume/body weight). The Ea/Ees was calculated. Results By end of study, 22 dogs died of cardiac-related causes with 67 dogs censored. Dogs with increased Ea/Ees (Ea/Ees >0.34; median survival time, 527 days; 95% confidence interval [CI], 322 days-not determinable) had a shorter survival time (P < .0001) than those without increased Ea/Ees (Ea/Ees <= 0.34; median survival time, >1112 days; 95% CI, not determinable). Multivariate Cox proportional hazard analysis showed that Ea/Ees, body weight, peak systolic mitral annular velocity, and the peak early diastolic transmitral velocity-to-peak early diastolic mitral annular velocity ratio were independent predictors of cardiac-related death among echocardiographic indices. Conclusions and Clinical Importance Inappropriate VAC assessed based on echocardiographically-estimated Ea/Ees is associated with a worse prognosis in dogs with MMVD. |
Type: | article |
URI: | http://hdl.handle.net/2115/83491 |
Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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