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A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy
| Title: | A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy |
| Authors: | Fukunaga, Hisanori Browse this author →KAKEN DB | | Butterworth, K. T. Browse this author | | McMahon, S. J. Browse this author | | Prise, K. M. Browse this author |
| Keywords: | Bystander effects | | grid therapy | | microbeam radiotherapy | | vascular damage |
| Issue Date: | Nov-2021 |
| Publisher: | Elsevier |
| Journal Title: | Clinical Oncology |
| Volume: | 33 |
| Issue: | 11 |
| Start Page: | 705 |
| End Page: | 712 |
| Publisher DOI: | 10.1016/j.clon.2021.08.011 |
| Abstract: | Microbeam radiotherapy (MRT) is the delivery of spatially fractionated beams that have the potential to offer significant improvements in the therapeutic ratio due to the delivery of micron-sized high dose and dose rate beams. They build on longstanding clinical experience of GRID radiotherapy and more recently lattice-based approaches. Here we briefly overview the preclinical evidence for MRT efficacy and highlight the challenges for bringing this to clinical utility. The biological mechanisms underpinning MRT efficacy are still unclear, but involve vascular, bystander, stem cell and potentially immune responses. There is probably significant overlap in the mechanisms underpinning MRT responses and FLASH radiotherapy that needs to be further defined. (c) 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83647 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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