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Hokkaido University Collection of Scholarly and Academic Papers >
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Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US
| Title: | Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US |
| Authors: | Yamazaki, Hiroyuki Browse this author | | Wada, Tsuneyuki Browse this author | | Asano, Hiroshi Browse this author | | Fujita, Hiromasa Browse this author | | Okamoto, Kazuhira Browse this author | | Watari, Hidemichi Browse this author →KAKEN DB |
| Keywords: | uterine cervical neoplasms | | human papillomavirus DNA tests | | early detection of cancer | | atypical squamous cells of the cervix | | urinalysis |
| Issue Date: | Oct-2021 |
| Publisher: | MDPI |
| Journal Title: | Diagnostics |
| Volume: | 11 |
| Issue: | 10 |
| Start Page: | 1895 |
| Publisher DOI: | 10.3390/diagnostics11101895 |
| Abstract: | Most uterine cervical cancers are caused by the persistent infection of the high-risk human papillomavirus (hrHPV). Thus, the hrHPV-DNA test, which examines specimens from the cervix, is the standard screening method as well as cytology in western countries. Urine sampling for the hrHPV-DNA test would be easier and help improving screening rates. This study prospectively investigated the concordance between urine and cervical hrHPV tests for patients with atypical squamous cells of undetermined significance (ASC-US) in cervical cytology. We recruited 338 women with the cytologic diagnosis of ASC-US and performed hrHPV-DNA tests to both samples from the uterine cervix and first void urine, using the Cobas 4800 system. In all hrHPV genotypes, the simple concordance rate was 90.8% (307/338) and the Kappa statistic value was 0.765, which shows substantial concordance. The positive concordance rate was 70.5% (74/105), which was the rate excluding women who had negative results in both tests. When limited to types 16 and 18, the simple concordance rate was 98.8% (334/338), and the Kappa statistical value was calculated to be 0.840, which showed almost perfect concordance. The positive concordance rate resulted in 81.8% (18/22). We conclude that the urine hrHPV-DNA test could substitute the cervical test in women with ASC-US.</p> |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83660 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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