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Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED) : a retrospective multi-institutional study

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Title: Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED) : a retrospective multi-institutional study
Authors: Hashimoto, Takayuki Browse this author →KAKEN DB
Demizu, Yusuke Browse this author
Numajiri, Haruko Browse this author →KAKEN DB
Isobe, Tomonori Browse this author
Fukuda, Shigekazu Browse this author
Wakatsuki, Masaru Browse this author
Yamashita, Haruo Browse this author
Murayama, Shigeyuki Browse this author →KAKEN DB
Takamatsu, Shigeyuki Browse this author
Katoh, Hiroyuki Browse this author
Murata, Kazutoshi Browse this author
Kohno, Ryosuke Browse this author
Arimura, Takeshi Browse this author
Matsuura, Taeko Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Keywords: Proton beam therapy
Carbon ion therapy
Cardiac implantable electronic devices
Electrical reset
Secondary neutron
Issue Date: 23-Dec-2021
Publisher: Springer
Journal Title: Japanese journal of radiology
Publisher DOI: 10.1007/s11604-021-01218-1
Abstract: Purpose To evaluate the outcomes of particle therapy in cancer patients with cardiac implantable electronic devices (CIEDs). Materials and methods From April 2001 to March 2013, 19,585 patients were treated with proton beam therapy (PBT) or carbon ion therapy (CIT) at 8 institutions. Of these, 69 patients (0.4%, PBT 46, CIT 22, and PBT + CIT 1) with CIEDs (64 pacemakers, 4 implantable cardioverter defibrillators, and 1 with a cardiac resynchronization therapy defibrillator) were retrospectively reviewed. All the patients with CIEDs in this study were treated with the passive scattering type of particle beam therapy. Results Six (13%) of the 47 PBT patients, and none of the 23 CIT patients experienced CIED malfunctions (p = 0.105). Electrical resets (7) and over-sensing (3) occurred transiently in 6 patients. The distance between the edge of the irradiation field and the CIED was not associated with the incidence of malfunctions in 20 patients with lung cancer. A larger field size had a higher event rate but the test to evaluate trends as not statistically significant (p = 0.196). Conclusion Differences in the frequency of occurrence of device malfunctions for patients treated with PBT and patients treated with CIT did not reach statistical significance. The present study can be regarded as a benchmark study about the incidence of malfunctioning of CIED in passive scattering particle beam therapy and can be used as a reference for active scanning particle beam therapy.
Type: article
URI: http://hdl.handle.net/2115/83675
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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