|
|
Hokkaido University Collection of Scholarly and Academic Papers >
International Institute for Zoonosis Control >
Peer-reviewed Journal Articles, etc >
Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2
| Title: | Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2 |
| Authors: | Ohno, Marumi Browse this author →KAKEN DB | | Sasaki, Michihito Browse this author →KAKEN DB | | Orba, Yasuko Browse this author →KAKEN DB | | Sekiya, Toshiki Browse this author | | Masum, Md. Abdul Browse this author | | Ichii, Osamu Browse this author →KAKEN DB | | Sawamura, Tatsuya Browse this author | | Kakino, Akemi Browse this author | | Suzuki, Yasuhiko Browse this author →KAKEN DB | | Kida, Hiroshi Browse this author →KAKEN DB | | Sawa, Hirofumi Browse this author →KAKEN DB | | Shingai, Masashi Browse this author →KAKEN DB |
| Keywords: | COVID-19 | | animal model | | aged Syrian hamster |
| Issue Date: | Nov-2021 |
| Publisher: | MDPI |
| Journal Title: | Viruses-Basel |
| Volume: | 13 |
| Issue: | 11 |
| Start Page: | 2137 |
| Publisher DOI: | 10.3390/v13112137 |
| Abstract: | Systemic symptoms have often been observed in patients with coronavirus disease 2019 (COVID-19) in addition to pneumonia, however, the details are still unclear due to the lack of an appropriate animal model. In this study, we investigated and compared blood coagulation abnormalities and tissue damage between male Syrian hamsters of 9 (young) and over 36 (aged) weeks old after intranasal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite similar levels of viral replication and inflammatory responses in the lungs of both age groups, aged but not young hamsters showed significant prolongation of prothrombin time and prominent acute kidney damage. Moreover, aged hamsters demonstrated increased intravascular coagulation time-dependently in the lungs, suggesting that consumption of coagulation factors causes prothrombin time prolongation. Furthermore, proximal urinary tract damage and mesangial matrix expansion were observed in the kidneys of the aged hamsters at early and later disease stages, respectively. Given that the severity and mortality of COVID-19 are higher in elderly human patients, the effect of aging on pathogenesis needs to be understood and should be considered for the selection of animal models. We, thus, propose that the aged hamster is a good small animal model for COVID-19 research. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83782 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
