|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Potential for transmission of sporadic Creutzfeldt-Jakob disease through peripheral routes
| Title: | Potential for transmission of sporadic Creutzfeldt-Jakob disease through peripheral routes |
| Authors: | Kobayashi, Atsushi Browse this author | | Munesue, Yoshiko Browse this author | | Shimazaki, Taishi Browse this author | | Aoshima, Keisuke Browse this author | | Kimura, Takashi Browse this author →KAKEN DB | | Mohri, Shirou Browse this author | | Kitamoto, Tetsuyuki Browse this author |
| Issue Date: | 12-Jul-2021 |
| Publisher: | Springer Nature |
| Journal Title: | Laboratory investigation |
| Volume: | 101 |
| Start Page: | 1327 |
| End Page: | 1330 |
| Publisher DOI: | 10.1038/s41374-021-00641-2 |
| Abstract: | Five sporadic Creutzfeldt-Jakob disease (CJD) strains have been identified to date, based on differences in clinicopathological features of the patients, the biochemical properties of abnormal prion proteins, and transmission properties. Recent advances in our knowledge about iatrogenic transmission of sporadic CJD have raised the possibility that the infectivity of sporadic CJD strains through peripheral routes is different from that of intracranial infection. To test this possibility, here we assessed systematically the infectivity of sporadic CJD strains through the peripheral route for the first time using a mouse model expressing human prion protein. Although the infectivity of the V2 and M1 sporadic CJD strains is almost the same in intracerebral transmission studies, the V2 strain infected more efficiently than the M1 strain through the peripheral route. The other sporadic CJD strains examined lacked infectivity. Of note, both the V2 and M1 strains showed preference for mice with the valine homozygosity at the PRNP polymorphic codon. These results indicate that the V2 strain is the most infectious sporadic CJD strain for infection through peripheral routes. In addition, these findings raise the possibility that individuals with the valine homozygosity at the PRNP polymorphic codon might have higher risks of infection through peripheral routes compared with the methionine homozygotes. Thus, preventive measures against the transmission of the V2 sporadic CJD strain will be important for the eradication of iatrogenic CJD transmission through peripheral routes. The authors sought to determine whether the infectivity of sporadic Creutzfeldt-Jakob disease prion strains through peripheral routes is different from that from intracranial infection. They found that among the strains, V2 is the most infectious through peripheral routes. Thus, preventive measures against transmission of this strain will be important for the eradication of iatrogenic transmission of Creutzfeldt-Jakob disease. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/83786 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 小林 篤史
|
