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SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role
| Title: | SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role |
| Authors: | Mizutani, Yusuke Browse this author →KAKEN DB | | Omagari, Daisuke Browse this author →KAKEN DB | | Hayatsu, Manabu Browse this author | | Nameta, Masaaki Browse this author | | Komiyama, Kazuo Browse this author →KAKEN DB | | Mikami, Yoshikazu Browse this author →KAKEN DB | | Ushiki, Tatsuo Browse this author →KAKEN DB |
| Keywords: | Carcinoma | | SLPI | | migration | | microscopic analysis | | Galectin4 |
| Issue Date: | 4-Oct-2020 |
| Publisher: | Taylor & Francis |
| Journal Title: | Cell Adhesion and Migration |
| Volume: | 14 |
| Issue: | 1 |
| Start Page: | 195 |
| End Page: | 203 |
| Publisher DOI: | 10.1080/19336918.2020.1829264 |
| Abstract: | To elucidate the underlying mechanism of secretory leukocyte protease inhibitor (SLPI)-induced cell migration, we compared SLPI-deleted human gingival carcinoma Ca9-22 (Delta SLPI) cells and original (wild-type: wt) Ca9-22 cells using several microscopic imaging methods and gene expression analysis. Our results indicated reduced migration of Delta SLPI cells compared to wtCa9-22 cells. The lamellipodia/dorsal ruffles were smaller and moved slower in Delta SLPI cells compared to wtCa9-22 cells. Furthermore, well-developed intermediate filament bundles were observed at the desmosome junction of Delta SLPI cells. In addition,Galectin4was strongly expressed in Delta SLPI cells, and its forced expression suppressed migration of wtCa9-22 cells. Taken together, SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83788 |
| Appears in Collections: | 総合IR本部 (Office of Institutional Research) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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