Title: | Hair follicle stem cell progeny heal blisters while pausing skin development |
Authors: | Fujimura, Yu Browse this author |
Watanabe, Mika Browse this author |
Ohno, Kota Browse this author |
Kobayashi, Yasuaki Browse this author |
Takashima, Shota Browse this author |
Nakamura, Hideki Browse this author |
Kosumi, Hideyuki Browse this author |
Wang, Yunan Browse this author |
Mai, Yosuke Browse this author |
Lauria, Andrea Browse this author |
Proserpio, Valentina Browse this author |
Ujiie, Hideyuki Browse this author |
Iwata, Hiroaki Browse this author |
Nishie, Wataru Browse this author |
Nagayama, Masaharu Browse this author |
Oliviero, Salvatore Browse this author |
Donati, Giacomo Browse this author |
Shimizu, Hiroshi Browse this author |
Natsuga, Ken Browse this author →KAKEN DB |
Keywords: | basement membrane zone |
epidermal stem cells |
epidermolysis bullosa |
Wnt signaling |
Issue Date: | 5-Jul-2021 |
Publisher: | EMBO Press |
Journal Title: | EMBO Reports |
Volume: | 22 |
Issue: | 7 |
Start Page: | e50882 |
Publisher DOI: | 10.15252/embr.202050882 |
Abstract: | Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it is not known whether this paradigm applies to growing tissue. Here, by employing blisters, we show that epidermal wounds heal at the expense of skin development. The regenerated epidermis suppresses the expression of tissue morphogenesis genes accompanied by delayed hair follicle (HF) growth. Lineage tracing experiments, cell proliferation dynamics, and mathematical modeling reveal that the progeny of HF junctional zone stem cells, which undergo a morphological transformation, repair the blisters while not promoting HF development. In contrast, the contribution of interfollicular stem cell progeny to blister healing is small. These findings demonstrate that HF development can be sacrificed for the sake of epidermal wound regeneration. Our study elucidates the key cellular mechanism of wound healing in skin blistering diseases. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/83789 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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