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Hair follicle stem cell progeny heal blisters while pausing skin development

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Title: Hair follicle stem cell progeny heal blisters while pausing skin development
Authors: Fujimura, Yu Browse this author
Watanabe, Mika Browse this author
Ohno, Kota Browse this author
Kobayashi, Yasuaki Browse this author
Takashima, Shota Browse this author
Nakamura, Hideki Browse this author
Kosumi, Hideyuki Browse this author
Wang, Yunan Browse this author
Mai, Yosuke Browse this author
Lauria, Andrea Browse this author
Proserpio, Valentina Browse this author
Ujiie, Hideyuki Browse this author
Iwata, Hiroaki Browse this author
Nishie, Wataru Browse this author
Nagayama, Masaharu Browse this author
Oliviero, Salvatore Browse this author
Donati, Giacomo Browse this author
Shimizu, Hiroshi Browse this author
Natsuga, Ken Browse this author →KAKEN DB
Keywords: basement membrane zone
epidermal stem cells
epidermolysis bullosa
Wnt signaling
Issue Date: 5-Jul-2021
Publisher: EMBO Press
Journal Title: EMBO Reports
Volume: 22
Issue: 7
Start Page: e50882
Publisher DOI: 10.15252/embr.202050882
Abstract: Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it is not known whether this paradigm applies to growing tissue. Here, by employing blisters, we show that epidermal wounds heal at the expense of skin development. The regenerated epidermis suppresses the expression of tissue morphogenesis genes accompanied by delayed hair follicle (HF) growth. Lineage tracing experiments, cell proliferation dynamics, and mathematical modeling reveal that the progeny of HF junctional zone stem cells, which undergo a morphological transformation, repair the blisters while not promoting HF development. In contrast, the contribution of interfollicular stem cell progeny to blister healing is small. These findings demonstrate that HF development can be sacrificed for the sake of epidermal wound regeneration. Our study elucidates the key cellular mechanism of wound healing in skin blistering diseases.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 夏賀 健

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