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Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
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| Title: | Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes |
| Authors: | Shinkai, Akihiro Browse this author | | Shinmei, Yasuhiro Browse this author →KAKEN DB | | Hirooka, Kiriko Browse this author | | Tagawa, Yoshiaki Browse this author →KAKEN DB | | Nakamura, Kayoko Browse this author | | Chin, Shinki Browse this author →KAKEN DB | | Ishida, Susumu Browse this author →KAKEN DB |
| Keywords: | Mitochondrial myopathy | | Encephalopathy | | Lactic acidosis and stroke-like episodes | | Optical coherence tomography | | Leber hereditary optic neuropathy | | Ganglion cell complex | | Homonymous hemianopia |
| Issue Date: | Jan-2021 |
| Publisher: | Elsevier |
| Journal Title: | Mitochondrion |
| Volume: | 56 |
| Start Page: | 47 |
| End Page: | 51 |
| Publisher DOI: | 10.1016/j.mito.2020.11.003 |
| Abstract: | Optical coherence tomography (OCT) is an imaging technique used to obtain three-dimensional information on the retina. In this article, we evaluated the structural neuro-retinal abnormalities, especially the thickness in the ganglion cell complex (GCC), in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The GCC thickness in MELAS patients was significantly thinner than that in normal controls even when they had no history of transient homonymous hemianopia. There was a negative correlation between GCC thickness and disease duration. In conclusion, OCT may be an effective tool to monitor and predict disease progression in MELAS patients. |
| Rights: | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/83790 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 新明 康弘
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