| Title: | Reliability of an ultrasonographical scoring system for diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease in patients with hematopoietic stem cell transplantation |
| Authors: | Iwai, Takahito Browse this author |
| Nishida, Mutsumi Browse this author →KAKEN DB |
| Sugita, Junichi Browse this author |
| Kudo, Yusuke Browse this author |
| Takasugi, Rika Browse this author |
| Yokota, Isao Browse this author →KAKEN DB |
| Takagi, Ryo Browse this author |
| Shibuya, Hitoshi Browse this author |
| Takahashi, Shuichiro Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Sinusoidal obstruction syndrome |
| Hepatic veno-occlusive disease |
| Hematopoietic stem cell transplantation |
| Operator reliability |
| Ultrasonography |
| Issue Date: | Jan-2021 |
| Publisher: | Springer |
| Journal Title: | Journal of medical ultrasonics |
| Volume: | 48 |
| Issue: | 1 |
| Start Page: | 45 |
| End Page: | 52 |
| Publisher DOI: | 10.1007/s10396-020-01071-1 |
| Abstract: | Purpose Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a fatal complication after hematopoietic stem cell transplantation. We previously reported the usefulness of an ultrasonographical (US) scoring system, the Hokkaido US-based scoring system consisting of ten parameters (HokUS-10): (1) hepatomegaly in the left lobe and (2) right lobe, (3) dilatation of the main portal vein (PV), (4) hepatofugal flow in the main PV, (5) decreased velocity of the PV, (6) dilatation of the para-umbilical vein (PUV), (7) appearance of blood flow signal in the PUV, (8) gallbladder (GB) wall thickening, (9) ascites, and (10) increased resistive index of the hepatic artery, for the diagnosis of SOS/VOD. However, the reliability of this system among operators remains elusive. Therefore, we prospectively evaluated the reliability of HokUS-10. Methods Twenty-four healthy volunteers and 40 patients with liver dysfunction were enrolled. Inter- and intra-operator reliabilities were analyzed using three sonographers. Results The median concordance rate of HokUS-10 among three sonographers and intra-operator in 24 volunteers was 92% (95% CI: 73-98%) and 98% (95% CI: 92-100%), respectively. In all 64 cases, in terms of the reliability between two sonographers for three representative US parameters (amount of ascites, GB wall thickening, and appearance of PUV blood flow signal), the median concordance rate was more than 98% (95% CI: 86-106%). Conclusion The inter- and intra-reliabilities of HokUS-10 were excellent. Thus, US might be a reliable tool for SOS/VOD diagnosis. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Journal of medical ultrasonics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10396-020-01071-1 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/83793 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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