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Serological methods for detection of infection with shrew-borne hantaviruses : Thottapalayam, Seewis, Altai, and Asama viruses

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Title: Serological methods for detection of infection with shrew-borne hantaviruses : Thottapalayam, Seewis, Altai, and Asama viruses
Authors: Wei, Zhouoxing Browse this author
Shimizu, Kenta Browse this author →KAKEN DB
Nishigami, Kumpei Browse this author
Tsuda, Yoshimi Browse this author
Sarathukumara, Yomani Browse this author
Muthusinghe, Devinda S. Browse this author
Gamage, Chandika D. Browse this author
Granathne, Lishanta Browse this author
Lokupathirage, Sithumini M. W. Browse this author
Nanayakkara, Nishanta Browse this author
Arikawa, Jiro Browse this author →KAKEN DB
Kikuchi, Fuka Browse this author
Tanaka-Taya, Keiko Browse this author
Suzuki, Motoi Browse this author
Morikawa, Shigeru Browse this author →KAKEN DB
Arai, Satoru Browse this author →KAKEN DB
Yoshimatsu, Kumiko Browse this author →KAKEN DB
Issue Date: Jan-2021
Publisher: Springer
Journal Title: Archives of virology
Volume: 166
Start Page: 275
End Page: 280
Publisher DOI: 10.1007/s00705-020-04873-3
Abstract: The infectivity of shrew-borne hantaviruses to humans is still unclear because of the lack of a serodiagnosis method for these viruses. In this study, we prepared recombinant nucleocapsid (rN) proteins of Seewis orthohantavirus, Altai orthohantavirus (ALTV), Thottapalayam thottimvirus (TPMV), and Asama orthohantavirus. Using monospecific rabbit sera, no antigenic cross-reactivity was observed. In a serosurvey of 104 samples from renal patients and 271 samples from heathy controls from Sri Lanka, one patient serum and two healthy control sera reacted with rN proteins of ALTV and TPMV, respectively. The novel assays should be applied to investigate potential infectivity of shrew-borne hantaviruses to humans.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Archives of Virology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉松 組子

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