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Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term

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Title: Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
Authors: Tanaka, Ikko Browse this author
Ono, Shoko Browse this author →KAKEN DB
Shimoda, Yoshihiko Browse this author
Inoue, Masaki Browse this author
Kinowaki, Sayoko Browse this author
Tsuda, Momoko Browse this author
Ono, Masayoshi Browse this author
Yamamoto, Keiko Browse this author
Shimizu, Yuichi Browse this author
Kato, Mototsugu Browse this author
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Dyspepsia
Helicobacter pylori
Eradication therapy
The elderly
Issue Date: 25-Nov-2021
Publisher: BioMed Central
Journal Title: BMC gastroenterology
Volume: 21
Issue: 1
Start Page: 445
Publisher DOI: 10.1186/s12876-021-02027-6
Abstract: Background Therapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to investigate dyspepsia symptoms and long-term effects of eradication in elderly patients. Methods This retrospective study included 496 patients who received H. pylori eradication therapy. The patients were divided into a group of elderly patients (group E: >= 65 years old) and a group of non-elderly patients (group N: < 65 years old). Abdominal symptoms were evaluated using a questionnaire about abdominal symptoms before eradication and after eradication (1-2 months and more than one year). Dyspepsia was defined as a score of 4 points or more for at least one of 4 items (postprandial fullness, early satiety, epigastric pain, and hunger pain). Improvement of symptoms was defined on the basis of changes in Global Overall Systems scores. Results There were no differences in abdominal symptoms before eradication between the two groups. Successful eradication improved symptoms in patients with dyspepsia within 2 months (in 75.6% (56/74) of the patients in group N and in 64.5% (20/31) of the patients in group E). The questionnaire showed that 80% (32/40) of the patients in group N and 60% (12/20) of the patients in group E had long-term relief of dyspepsia. The scores for abdominal symptoms in group E continued to improve for a mean period of 54.8 months after eradication. Conclusions Eradication of H. pylori age-independently improved dyspepsia symptoms for the long term.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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