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Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease

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Title: Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease
Authors: Abe, Yuki Browse this author
Suzuki, Masaru Browse this author →KAKEN DB
Shima, Hiroshi Browse this author
Shiraishi, Yusuke Browse this author
Tanabe, Naoya Browse this author
Sato, Susumu Browse this author
Shimizu, Kaoruko Browse this author
Kimura, Hirokazu Browse this author
Makita, Hironi Browse this author
Hirai, Toyohiro Browse this author
Konno, Satoshi Browse this author
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: annual body weight change
body mass index
chronic obstructive pulmonary disease
weight loss
Issue Date: Dec-2021
Publisher: Dove Medical Press
Journal Title: International journal of chronic obstructive pulmonary disease
Volume: 16
Start Page: 3243
End Page: 3253
Publisher DOI: 10.2147/COPD.S338908
Abstract: Purpose: Low body mass index (BMI) has been reported to be associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). In contrast, a detailed analysis of the association between body weight change over time and prognosis is not sufficient, particularly in Japanese patients with COPD who have been reported to be much thinner compared to Westerners. This study aimed to investigate the relationship between annual body weight change and long-term prognosis in Japanese patients with COPD in two independent cohorts. Patients and Methods: We analyzed 279 patients with COPD who participated in the Hokkaido COPD cohort study as a discovery cohort. We divided participants into three groups according to quartiles of annual body weight change calculated by the data from the first 5 years: weight loss group (<-0.17 kg/year), no change group (-0.17 to <= 0.20 kg/year), and weight gain group (>0.20 kg/year). The association between annual body weight change and prognosis was replicated in the Kyoto University cohort (n = 247). Results: In the Hokkaido COPD cohort study, the weight loss group had significantly worse mortality than the other groups, whereas there was no difference in BMI at baseline. In the multivariate analysis, annual body weight change was an independent risk factor for all-cause mortality, which was confirmed in the Kyoto University cohort. Conclusion: Annual body weight loss is associated with poor prognosis in Japanese patients with COPD, independent of baseline BMI. Longitudinal assessment of body weight is important for the management of COPD.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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