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Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

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Title: Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka
Authors: Muthusinghe, Devinda S. Browse this author
Shimizu, Kenta Browse this author
Lokupathirage, Sithumini M. W. Browse this author
Wei, Zhouoxing Browse this author
Sarathkumara, Yomani D. Browse this author
Fonseka, G. R. Amanda Browse this author
Senarathne, Pavani Browse this author
Koizumi, Nobuo Browse this author
Kawakami, Tomonori Browse this author
Koizumi, Akio Browse this author
Wickramasinghe, Chaminda Browse this author
Ebihara, Hideki Browse this author
Matsuno, Keita Browse this author
Tsuda, Yoshimi Browse this author
Arikawa, Jiro Browse this author
Gamage, Chandika D. Browse this author
Yoshimatsu, Kumiko Browse this author →KAKEN DB
Keywords: hantavirus
Mus booduga
Thailand orthohantavirus
Anjozorobe hantavirus
Issue Date: Oct-2021
Publisher: MDPI
Journal Title: Viruses-Basel
Volume: 13
Issue: 10
Start Page: 1984
Publisher DOI: 10.3390/v13101984
Abstract: We reported the genetic evidence of circulating hantaviruses from small mammals captured in a chronic kidney disease of unknown etiology (CKDu) hotspot area of Sri Lanka. The high seroprevalence of anti-hantavirus antibodies against Thailand orthohantavirus (THAIV) has been reported among CKDu patients and rodents in Sri Lankan CKDu hotspots. We captured 116 small mammals from CKDu endemic regions in the Polonnaruwa District of Sri Lanka. Seven animals (five out of 11 Mus booduga and two out of 99 Rattus rattus) were PCR-positive for the hantavirus. A rat-borne sequence was grouped with a THAIV-like Anjozorobe virus. In contrast, Mus-borne sequences belonged to the THAIV lineage, suggesting a novel orthohantavirus species according to the phylogenetic analyses and whole-genome comparisons. Our genetic evidence indicates the presence of two THAIV-related viruses circulating in this CKDu endemic area, suggesting a basis for further investigations to identify the infectious virus in patients with CKDu and the CKDu induction mechanism of these viruses.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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