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Hokkaido University Collection of Scholarly and Academic Papers >
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Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study)
| Title: | Lowering of blood pressure and pulse rate by switching from DPP-4 inhibitor to luseogliflozin in patients with type 2 diabetes complicated with hypertension: A multicenter, prospective, randomized, open-label, parallel-group comparison trial (LUNA study) |
| Authors: | Hashimoto-Kameda, Reina Browse this author | | Cho, Kyu Yong Browse this author | | Nomoto, Hiroshi Browse this author | | Nakamura, Akinobu Browse this author | | Omori, Kazuno Browse this author | | Nagai, So Browse this author | | Edagawa, Sachiko Browse this author | | Kawata, Shinichiro Browse this author | | Takeuchi, Jun Browse this author | | Kameda, Hiraku Browse this author | | Kurihara, Yoshio Browse this author | | Aoki, Shin Browse this author | | Atsumi, Tatsuya Browse this author →KAKEN DB | | Miyoshi, Hideaki Browse this author →KAKEN DB |
| Keywords: | inhibitor | | Type 2 diabetes | | Hypertension | | Sodium-glucose cotransporter-2 |
| Issue Date: | Oct-2021 |
| Publisher: | Elsevier |
| Journal Title: | Diabetes research and clinical practice |
| Volume: | 180 |
| Start Page: | 109069 |
| Publisher DOI: | 10.1016/j.diabres.2021.109069 |
| Abstract: | Aims: Sodium-glucose cotransporter-2 inhibitor (SGLT2i) reduces clinic blood pressure (BP), but the effects on BP circadian rhythm remain unclear. The present study aimed to determine the nighttime antihypertensive effect of SGLT2i compared with dipeptidyl peptidase-4 inhibitor (DPP-4i) in patients with type 2 diabetes and hypertension. Materials and Methods: In this randomized, open-label, parallel-group trial, patients treated with DPP-4i were either switched to luseogliflozin 2.5 mg/day (Luseo group; n = 30) or continued DPP-4i (DPP-4i group; n = 26). The patients undertook 24-h ambulatory BP monitoring before and 8 weeks after the group allocation. The primary endpoint was mean change in nighttime systolic BP (SBP). Results: Nighttime SBP, as well as daytime SBP, was significantly reduced in the Luseo group compared with the DPP-4i group (nighttime,-4.0 +/- 11.4 vs. 3.6 +/- 10.7 mmHg, P = 0.01; day time,-4.4 +/- 10.9 vs. 3.7 +/- 11.9 mmHg, P = 0.01). Similarly, nighttime pulse rate (PR) was significantly reduced in the Luseo group (-2.0 +/- 4.8 vs. 0.9 +/- 4.8 bpm, P = 0.03). The proportion of patients with abnormal BP circadian rhythms (non-dipper pattern plus riser pattern) was significantly lower in the Luseo group (36.6% vs. 56.7%, P < 0.05). Conclusions: Switching from DPP-4i to luseogliflozin decreased nighttime SBP and PR; moreover, BP circadian rhythm was improved. (C) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83964 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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