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PIWI-Interacting RNAs (piRNAs) : Promising Applications as Emerging Biomarkers for Digestive System Cancer

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Title: PIWI-Interacting RNAs (piRNAs) : Promising Applications as Emerging Biomarkers for Digestive System Cancer
Authors: Cai, Aiting Browse this author
Hu, Yuhao Browse this author
Zhou, Zhou Browse this author
Qi, Qianyi Browse this author
Wu, Yixuan Browse this author
Dong, Peixin Browse this author →KAKEN DB
Chen, Lin Browse this author
Wang, Feng Browse this author
Keywords: Piwi-interacting RNA
cancer biomarker
digestive system cancer
therapeutic target
Issue Date: 27-Jan-2022
Publisher: Frontiers
Journal Title: Frontiers in Molecular Biosciences
Volume: 9
Start Page: 848105
Publisher DOI: 10.3389/fmolb.2022.848105
Abstract: PIWI-interacting RNAs (piRNAs) are a novel type of small non-coding RNAs (sncRNAs), which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were originally discovered in germline cells and are thought to be essential regulators for germline preservation, they can also influence gene expression in somatic cells. An increasing amount of data has shown that the dysregulation of piRNAs can both promote and repress the emergence and progression of human cancers through DNA methylation, transcriptional silencing, mRNA turnover, and translational control. Digestive cancers are currently a major cause of cancer deaths worldwide. piRNAs control the expression of essential genes and pathways associated with digestive cancer progression and have been reported as possible biomarkers for the diagnosis and treatment of digestive cancer. Here, we highlight recent advances in understanding the involvement of piRNAs, as well as potential diagnostic and therapeutic applications of piRNAs in various digestive cancers.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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