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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
PIWI-Interacting RNAs (piRNAs) : Promising Applications as Emerging Biomarkers for Digestive System Cancer
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | PIWI-Interacting RNAs (piRNAs) : Promising Applications as Emerging Biomarkers for Digestive System Cancer |
| Authors: | Cai, Aiting Browse this author | | Hu, Yuhao Browse this author | | Zhou, Zhou Browse this author | | Qi, Qianyi Browse this author | | Wu, Yixuan Browse this author | | Dong, Peixin Browse this author →KAKEN DB | | Chen, Lin Browse this author | | Wang, Feng Browse this author |
| Keywords: | Piwi-interacting RNA | | cancer biomarker | | diagnosis | | prognosis | | digestive system cancer | | therapeutic target |
| Issue Date: | 27-Jan-2022 |
| Publisher: | Frontiers |
| Journal Title: | Frontiers in Molecular Biosciences |
| Volume: | 9 |
| Start Page: | 848105 |
| Publisher DOI: | 10.3389/fmolb.2022.848105 |
| Abstract: | PIWI-interacting RNAs (piRNAs) are a novel type of small non-coding RNAs (sncRNAs), which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were originally discovered in germline cells and are thought to be essential regulators for germline preservation, they can also influence gene expression in somatic cells. An increasing amount of data has shown that the dysregulation of piRNAs can both promote and repress the emergence and progression of human cancers through DNA methylation, transcriptional silencing, mRNA turnover, and translational control. Digestive cancers are currently a major cause of cancer deaths worldwide. piRNAs control the expression of essential genes and pathways associated with digestive cancer progression and have been reported as possible biomarkers for the diagnosis and treatment of digestive cancer. Here, we highlight recent advances in understanding the involvement of piRNAs, as well as potential diagnostic and therapeutic applications of piRNAs in various digestive cancers. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83994 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 董 培新
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