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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Anatomy and histology of the foramen of ovarian bursa opening to the peritoneal cavity and its changes in autoimmune disease‐prone mice
| Title: | Anatomy and histology of the foramen of ovarian bursa opening to the peritoneal cavity and its changes in autoimmune disease‐prone mice |
| Authors: | Marina, Hosotani Browse this author | | Osamu, Ichii Browse this author | | Teppei, Nakamura Browse this author | | Namba, Takashi Browse this author | | Islam, Md Rashedul Browse this author | | Elewa, Yaser Hosny Ali Browse this author | | Watanabe, Takafumi Browse this author | | Ueda, Hiromi Browse this author | | Kon, Yasuhiro Browse this author →KAKEN DB |
| Keywords: | 3D morphometry | | mesosalpinx | | ovarian bursa | | oviduct | | reproduction |
| Issue Date: | Jan-2021 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of Anatomy |
| Volume: | 238 |
| Issue: | 1 |
| Start Page: | 73 |
| End Page: | 85 |
| Publisher DOI: | 10.1111/joa.13299 |
| Abstract: | The ovarian bursa is a small peritoneal cavity enclosed by the mesovarium and mesosalpinx, which surrounds the ovaries and oviductal infundibulum in mammals. The ovarian bursa is considered as the structure facilitating the transport of ovulated oocytes into the oviduct. Our previous study revealed reduced oocyte pick-up function in the oviduct of lupus-prone MRL/MpJ-Fas(lpr)(/)(lpr)mouse, suggesting the possibility of an escape of ovulated oocytes into the peritoneal cavity, despite the presence of an almost complete ovarian bursa in the mouse. In this study, we revealed anatomical and histological characteristics of the ovarian bursa in C57BL/6 N, MRL/MpJ, and MRL/MpJ-Fas(lpr)(/)(lpr)mice. All strains had the foramen of ovarian bursa (FOB), with a size of approximately 0.04 to 0.12 cm(2), surrounded by the ligament of ovarian bursa (LOB), which is part of the mesosalpinx. The LOB was partially lined with the cuboidal mesothelial cells and consisted of a thick smooth muscle layer in all strains. In 6-month-old MRL/MpJ-Fas(lpr)(/)(lpr)mice, in which the systemic autoimmune abnormality deteriorated and oocyte pick-up function was impaired, the size of the FOB tended to be larger than that of other strains. Additionally, in MRL/MpJ-Fas(lpr)(/)(lpr)mice at 6 months of age, there was infiltration by numerous immune cells in the mesosalpinx suspending the isthmus; however, the LOB prevented severe inflammation and showed deposition of collagen fibers. These results not only indicate that the FOB is a common structure within mice, but also imply the physiological function of the LOB and its role in maintaining the microenvironment around the ovary, as well as regulating healthy reproduction. |
| Rights: | This is the peer reviewed version of the following article: Hosotani, M, Ichii, O, Nakamura, T et al. Anatomy and histology of the foramen of ovarian bursa opening to the peritoneal cavity and its changes in autoimmune disease‐prone mice. J. Anat. 2020; 238: 73– 85, which has been published in final form at https://doi.org/10.1111/joa.13299 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/84017 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 昆 泰寛
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