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Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis

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Title: Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis
Authors: Koyanagawa, Kazuhiro Browse this author
Naya, Masanao Browse this author →KAKEN DB
Aikawa, Tadao Browse this author
Manabe, Osamu Browse this author
Kuzume, Masato Browse this author
Ohira, Hiroshi Browse this author
Tsujino, Ichizo Browse this author
Tamaki, Nagara Browse this author
Anzai, Toshihisa Browse this author →KAKEN DB
Keywords: Cardiac sarcoidosis
Electrocardiography-gated single-photon emission computed tomography
fluorideoxyglucose positron emission tomography-computed tomography
Phase analysis
Major adverse cardiac events
Issue Date: Feb-2021
Publisher: Springer
Journal Title: Journal of nuclear cardiology
Volume: 28
Issue: 1
Start Page: 128
End Page: 136
Publisher DOI: 10.1007/s12350-019-01660-9
Abstract: Background We aimed to determine the correlation between phase analysis, reflecting the heterogeneity of perfusion defects, and the dyssynchrony of the left ventricle wall motion, and adverse cardiac events in cardiac sarcoidosis (CS) patients. Methods Fifty-seven consecutive patients with diagnosed CS (64 [IQR 55-71] years old, 14 males), who underwent F-18-FDG PET/CT and ECG-gated SPECT, were studied. FDG PET was analysed to measure cardiac metabolic volume (CMV), and total lesion glycolysis (TLG). The SPECT findings, such as LVEF, Summed Rest Score (SRS), bandwidth (BW) were evaluated. Results The median of BW was 56 degrees (IQR 40-95). BW showed a strong inverse correlation with LVEF (r = - 0.60, P < 0.0001), and positive correlation with SRS (r = 0.82, P < 0.0001). However, there were no significant correlations between BW and CMV or TLG. The Kaplan-Meier curves revealed a significantly higher rate of MACE in the high BW group (BW > 56 degrees) than the low BW group (BW <= 56 degrees) (15.1%/years vs. 4.4%/years, P = 0.025). In multivariable analysis, BW was a significant independent predictor of MACE (P = 0.015). Conclusion Phase analysis on gated SPECT was a significant and independent predictor of MACE in patients with CS.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Journal of nuclear cardiology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 納谷 昌直

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