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The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma

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Title: The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma
Authors: Nakamaru, Yuji Browse this author →KAKEN DB
Suzuki, Masanobu Browse this author →KAKEN DB
Kano, Satoshi Browse this author
Mizumachi, Takatsugu Browse this author
Tsushima, Nayuta Browse this author
Suzuki, Takayoshi Browse this author
Honma, Aya Browse this author
Nakazono, Akira Browse this author
Kimura, Shogo Browse this author
Onimaru, Rikiya Browse this author
Yasuda, Koichi Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Keywords: Squamous cell carcinoma
Endoscopic sinus surgery
Nasal cavity
Paranasal sinus
Surgical margin
Issue Date: 1-Feb-2021
Publisher: Elsevier
Journal Title: Auris nasus larynx
Volume: 48
Issue: 1
Start Page: 131
End Page: 137
Publisher DOI: 10.1016/j.anl.2020.06.014
Abstract: Objective: Despite of rapid advances in endoscopic surgery, the gold standard for sinonasal squamous cell carcinoma (SNSCC) surgery has remained the open approach with en-block resection due to the aggressive nature of SNSCC, including frequent recurrence and high mortality rate. For that reason, few studies have focused on SNSCC treated by endoscopic surgery alone. The objective of this study was to evaluate the usefulness of endoscopic surgery for patients with SNSCC. Methods: A retrospective analysis was performed for 15 consecutive SNSCC patients who underwent endoscopic surgery without an open approach. We carefully selected patients whose tumor attachment sites could be fully visualized and completely resected through an endonasal approach. Results: Of the fifteen patients, 4 patients (27%) were diagnosed with T1, 7 (47%) with T2, 4 (27%) with T3, and no patients with T4a or T4b disease. Four of the 15 (27%) patients showed positive surgical margins. The 5-yr overall survival, disease-specific survival, and local control rate was 72.4%, 79.6%, and 92.9%, respectively. The 5-yr disease-specific survival for T1, T2, and T3 disease was 100% and 75% and 75%, respectively. Patients with negative surgical margins had a better disease-specific survival rate than did those with positive surgical margins (p = 0.0253). Conclusion: Endoscopic surgery for patients with SNSCC appears to afford an effective method in selected cases. The achievement of negative surgical margins with a good view of the tumor attachment site was considered to be critical to the management of SNSCC. (c) 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.
Rights: ©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中丸 裕爾

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