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Hokkaido University Collection of Scholarly and Academic Papers >
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Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens
| Title: | Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens |
| Authors: | Fujisawa, Sotaro Browse this author | | Murata, Shiro Browse this author →KAKEN DB | | Isezaki, Masayoshi Browse this author | | Ariizumi, Takuma Browse this author | | Sato, Takumi Browse this author | | Oishi, Eiji Browse this author | | Taneno, Akira Browse this author | | Maekawa, Naoya Browse this author →KAKEN DB | | Okagawa, Tomohiro Browse this author →KAKEN DB | | Ichii, Osamu Browse this author →KAKEN DB | | Konnai, Satoru Browse this author →KAKEN DB | | Ohashi, Kazuhiko Browse this author →KAKEN DB |
| Keywords: | Dermanyssus gallinae | | poultry red mite | | cystatin | | vaccine | | cocktail vaccine |
| Issue Date: | Dec-2021 |
| Publisher: | MDPI |
| Journal Title: | Vaccines |
| Volume: | 9 |
| Issue: | 12 |
| Start Page: | 1472 |
| Publisher DOI: | 10.3390/vaccines9121472 |
| Abstract: | Poultry red mite (PRM; Dermanyssus gallinae) is a hazardous, blood-sucking ectoparasite of birds that constitutes a threat to poultry farming worldwide. Acaricides, commonly used in poultry farms to prevent PRMs, are not effective because of the rapid emergence of acaricide-resistant PRMs. However, vaccination may be a promising strategy to control PRM. We identified a novel cystatin-like molecule in PRMs: Dg-Cys. Dg-Cys mRNA expression was detected in the midgut and ovaries, in all stages of life. The PRM nymphs that were artificially fed with the plasma from chickens that were immunized with Dg-Cys in vitro had a significantly reduced reproductive capacity and survival rate. Moreover, combination of Dg-Cys with other antigen candidates, like copper transporter 1 or adipocyte plasma membrane-associated protein, enhanced vaccine efficacies. vaccination and its application as an antigen for cocktail vaccines could be an effective strategy to reduce the damage caused by PRMs in poultry farming. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84052 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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