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5-HT1A receptor agonist affects fear conditioning through stimulations of the postsynaptic 5-HT1A receptors in the hippocampus and amygdala

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Title: 5-HT1A receptor agonist affects fear conditioning through stimulations of the postsynaptic 5-HT1A receptors in the hippocampus and amygdala
Authors: Li, XiaoBai Browse this author
Inoue, Takeshi Browse this author →KAKEN DB
Abekawa, Tomohiro Browse this author
Weng, ShiMin Browse this author
Nakagawa, Shin Browse this author →KAKEN DB
Izumi, Takeshi Browse this author
Koyama, Tsukasa Browse this author
Keywords: Flesinoxan
5-HT1A receptor agonist
fear conditioning
the hippocampus
the amygdala
the medial prefrontal cortex
Issue Date: 17-Feb-2006
Publisher: Elsevier
Journal Title: European Journal of Pharmacology
Volume: 532
Issue: 1-2
Start Page: 74
End Page: 80
Publisher DOI: 10.1016/j.ejphar.2005.12.008
PMID: 16460727
Abstract: Evidence from preclinical and clinical studies has shown that 5-HT1A receptor agonists have anxiolytic actions. The anxiolytic actions of 5-HT1A receptor agonists have been tested by our previous studies using fear conditioning. However, little is known about the brain regions of anxiolytic actions of 5-HT1A receptor agonists in this paradigm. In the present study, we investigated the effects of bilateral microinjections of flesinoxan, a selective 5-HT1A receptor agonist, into the hippocampus, amygdala and medial prefrontal cortex on the expression of contextual conditioned freezing and the defecation induced by conditioned fear stress in rats. These results reveal that both intrahippocampal and intraamygdala injections of flesinoxan decreased the expression of conditioned freezing, while injections into the medial prefrontal cortex did not. In addition, intraamygdala injection of flesinoxan attenuated the increased defecation induced by conditioned fear, but injections into the hippocampus and medial prefrontal cortex failed. These results suggest that flesinoxan exerts its anxiolytic actions in the fear conditioning through stimulations of the postsynaptic 5-HT1A receptors in the hippocampus and amygdala.
Relation: http://www.sciencedirect.com/science/journal/00142999
Type: article (author version)
URI: http://hdl.handle.net/2115/8408
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井上 猛

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